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ERICH5
Glutamate Rich Protein 5  is a protein in humans encoded by the ERICH5 gene, also known as Chromosome 8 open reading frame 47 (C8orf47).

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Gene
The ERICH5 gene is located on human chromosome 8 at 8q22.2. ERICH5 contains three exons and has two isoforms.1 The longest isoform, isoform 1, has 1,550 base pairs and isoform 2 which lacks the third and final exon has 596 base pairs.2  ERICH5 is also known by these aliases, C8orf47, and glutamate rich 5. 1

Homology
There are no known paralogs of the ERICH5 gene. True orthologs of ERICH5 have only been identified among mammalian species. Distant orthologs have been found as far back as Clade Aves and Re

ptilia. These distant orthologs contain only the third exon of the ERICH5 human gene. ERICH5 contains one conserved domain, a domain of unknown function called DUF4573.2

Protein
The ERICH5 protein is predicted to be localized in the nucleus. There are a number of predicted phosphorylation sites on the ERICH5. Several kinases including PKC, cdc2, PKA, ATM, and DNAPK have been predicted to interact with the ERICH5 protein. ERICH5 is also predicted to undergo O-glycosylation.3 The majority of the protein is predicted to have a secondary structure of disordered coils with several short spans forming alpha helices at the N terminus and a two short beta sheets at the C terminus.4,5

Expression
Data suggests that ERICH5 is expressed in most tissue but has the highest levels of expression in the liver, fetal liver, pancreas, and retina. It has also been found that ERICH5 is expressed in higher levels in embryos and children than in adults.6

Interacting Protein
Yeast 2 hybrid screening has predicted that ERICH5 interacts with  a protein called KEAP1, an adapter protein for E3 ubiquitin ligase. ERICH5 has been predicted to interact with a number of other proteins through affinity chromatography. 7

Clinical Significance
Increased expression of the ERICH5 gene has been found to be associated with alcoholic hepatitis, non-neoplasia, leukemia, and several other tumor types.6