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Uwe T. Bornscheuer (born January 14, 1964) in Frankenhain, Hessen is a German chemist. Since 1999 he is full professor at the Institute of Biochemistry and head of the department Biotechnology and Enzyme Catalysis at the University of Greifswald. His research focuses on enzyme engineering and the application of enzymes in organic synthesis.

Early life and education
He received his diploma degree in chemistry in 1990 and his Ph.D. degree in Technical Chemistry in 1993 both from the University of Hannover in Germany. In 1994 he performed postdoctoral studies at the University of Nagoya in Japan, then moved to the University of Stuttgart, where he finished his habilitation in Technical Biochemistry in 1998.

Career and research
From 2002 until 2008 Prof. Bornscheuer was the Managing Director of the Institute of Biochemistry at the University of Greifswald. In 2004 he received two offers for C4Professorship at the Technical University of Freiberg and Hamburg-Harburg (Germany), which he declined and accepted an equivalent offer at the University of Greifswald.

From April 2018 until March 2020 he was the Vice Dean of the Faculty of Mathematics and Natural Sciences at the University of Greifswald and since April 2020 he is the chairman of the Senate of the University of Greifswald.

Uwe Bornscheuer has published over 550 peer-reviewed research articles, more than 40 book chapters and has filed >50 patent applications. He has received several awards including most recently the “2022 Enzyme Engineering Award”.

The major research theme in the Bornscheuer group is identifying and optimizing enzymes through protein engineering for applications in organic synthesis, lipid modification, the enzymatic degradation of complex marine polysaccharides and enzymatic recycling of plastics. He has pioneered many methods of protein engineering, including a range of new high-throughput screening methods, computational tools to design libraries of protein variants and the application of these methods to alter the regio-, chemo- and stereoselectivity of enzymes for various applications (Zitate zu Publikationen einfügen).

He is currently member of the Scientific Advisory Boards of the Toulouse White Biotechnology center and of the company Carbios (France) and he is a cofounder and Chairman of the Advisory Board of the company Enzymicals AG in Greifswald. He is also member of the review board for Biochemistry of the German Research Foundation (DFG) and since 2021 member of the selection committees of the Novo Nordisk Foundation.

Personal life
Uwe Bornscheuer lives in Greifswald and is married with Dr. Tanja Kummer. The couple has a daughter Annika (born 1997). His hobbies are sailing and motorbike riding.

Honors and awards

 * Kaufmann Memorial Lecture (2023)
 * Distinguished Visting Project Professor, Kyoto University (2023)
 * Ewha Global Fellow, Ewha Womans University, Seoul (2023)
 * Enzyme Engineering Award 2022
 * European Lipid Technology Award 2021
 * Chemistry Europe Fellow (2020)
 * Greifswald Research Award (2018) (see also ACIE article).
 * Adjunct Professor, VISTEC, Rayong, Thailand (VISTEC).
 * Stephen S. Chang Award (AOCS, USA), 2015
 * Wilhelm-Normann-Medal of the German Society of Fat Science e.V. (DGF).
 * Chevreul-Medal from the French Society of Lipid Research (SFEL), Paris, France 2012
 * Biocat2008 Award received at Biocat2008 conference, Hamburg-Harburg, Germany.
 * Two fellowships from the Japanese Society for the Promotion of Science (JSPS), 1993, 2010
 * Stipends of the ‘Fonds der Chemischen Industrie’, FCI, Germany (four times), 1991, 1996-1998

Further Memberships

 * Currently member of the editorial board of the journals: “Sci. Rep.”, "Appl. Microbiol. Biotechnol.", "J. Mol. Catal.", "J. Am. Oil Chem. Soc.", "Enzyme Microb. Technol", Honorary Editor of “Eur. J. Lipid Sci. Technol.“
 * 2016-2019: Review Editor of the journal "Process Biochem."
 * 2009-2017: Editorial Board Chairman of the journal "ChemCatChem"
 * 2007-2016: Editor-in-Chief of "Eur. J. Lipid Sci. Technol.“
 * 2007-2009: President of the German Society for Fat Science, DGF, Frankfurt
 * 2014-2018: Board member of the German Catalysis Society (Deutsche Gesellschaft für Katalyse)
 * Since 05/2019: Member of the selection committee of ‘Deutsche Bundesstiftung Umwelt’ for PhD stipends
 * Since 04/2020: Member of the DFG Review Board (Fachkollegiat) for Biochemistry (FG-201)

Books

 * Weber/Bornscheuer/Wei (Eds.), Enzymatic Plastic Degradation. Academic Press, 2021
 * Bornscheuer, U.T. (Ed.), Lipid Modification by Enzymes & Engineered Microbes, AOCS Press/Academic Press, 2018
 * Bornscheuer/Höhne (Eds.), Protein Engineering, Methods Enzymol., Humana Press, 2017
 * Lutz/Bornscheuer (Ed.), Protein Engineering Handbook, Wiley, 2009 and 2012 (Three volumes)
 * Kasche/Bornscheuer/Buchholz, Biocatalysts and Enzyme Technology, Wiley, 1st (2005) & 2nd (2012) Edition
 * Bornscheuer/Kazlauskas, Hydrolases in Organic Synthesis, 1st (1999) & 2nd (2006) Edition, Wiley
 * Bornscheuer (Ed.), Enzymes in Lipid Modification, Wiley, 2000

Selected publications
Buller, R., Lutz, S., Kazlauskas, R.J., Snajdrova, R., Moore, J.C., Bornscheuer, U.T. (2023), From nature to industry: harnessing enzymes for biocatalytic processes, Science, 382, eadh8615

Ao, Y.F., Pei, S., Xiang, C., Menke, M.J., Shen, L., Sun, C., Dörr, M., Born, S., Höhne, M., Bornscheuer, U.T. (2023), Structure- and data-driven protein engineering of transaminases for improving activity and stereoselectivity, Angew. Chem. Int. Ed., 62, e202301660, link; Struktur- und Daten-basiertes Protein Engineering von Transaminasen zur Verbesserung von Aktivität und Stereoselektivität, Angew. Chem.135, e202301660

Branson, Y., Söltl, S., Buchmann, C., Wei, R., Schaffert, L., Badenhorst, C.P.S., Reisky, L., Jäger, G., Bornscheuer, U.T. (2023), Urethanases for the enzymatic hydrolysis of low molecular weight carbamates and the recycling of polyurethanes, Angew. Chem. Int. Ed., 62, e202216220, link; Urethanasen für die enzymatische Hydrolyse niedermolekularer Carbamate und das Recycling von Polyurethanen, Angew. Chem., 135, e202216220

Wu, S. Xiang, C., Zhou, Y., Khan, M.S.H., Liu, W., Feiler, C.G., Wei, R., Weber, G., Höhne, M., Bornscheuer, U.T. (2022), A growth selection for the directed evolution of amine-forming or converting enzymes, Nature Commun., 13, 7458

Müller, H., Godehard, S.P., Palm, G.J., Berndt, L., Badenhorst, C.P.S., Becker, A.K., Lammers, M., Bornscheuer, U.T. (2021), Discovery and design of family VIII carboxylesterases as highly efficient acyltransferases, Angew. Chem. Int. Ed., 60, 2013-2017, link; Entdeckung und Design promiskuitiver Acyltransferase-Aktivität in Carboxylesterasen der Familie VIII, Angew. Chem., 133, 2041-2045

Tang, Q., Grathwol, C.W., Aslan-Üzel, A.S., Wu, S., Link, A., Pavlidis, I.V., Badenhorst, C.P.S., Bornscheuer, U.T., (2021), Directed evolution of a halide methyltransferase enables biocatalytic synthesis of diverse SAM analogues, Angew. Chem. Int. Ed., 60, 1524-1527, link; Die gerichtete Evolution einer Halogenid-Methyltransferase erlaubt die biokatalytische Synthese diverser SAM-Analoga, Angew. Chem., 133, 1547-1551

Wu, S., Snajdrova, R., Moore, J., Baldenius, K., Bornscheuer, U.T. (2021), Biocatalysis: Enzymatic synthesis for industrial applications, Angew. Chem. Int. Ed., 60, 88-119, link; Biokatalyse: Enzymatische Synthese für industrielle Anwendungen, Angew. Chem., 113, 89-123

Yi., D., Bayer, T., Badenhorst, C.P.S., Wu, S., Dörr, M., Höhne, M., Bornscheuer, U.T. (2021), Recent trends in biocatalysis, Chem. Soc. Rev., 50, 8003-8049

Wei, R., Tiso, T., Bertling, J., O’Connor, K., Blank, L.M., Bornscheuer, U.T. (2020), Possibilities and limitations of biotechnological plastic degradation and recycling, Nature Catal.

Müller, H., Becker, A.K, Palm, G.J., Berndt, L., Badenhorst, C.P.S., Godehard, S.P., Reisky, L., Lammers, M., Bornscheuer, U.T. (2020), Sequence-based prediction of promiscuous acyltransferase activity in hydrolases, Angew. Chem. Int. Ed., 59, 11607-11612 link; Angew. Chem., 132, 11704-11709

Reisky, L., Préchoux, A., Zühlke, A.K., Bäumgen, M., Robb, C.S., Gerlach, N., Roret, T., Stanetty, C., Larocque, R., Michel, G., Song, T., Markert, S., Unfried, F., Mihovilovic, M.D., Trautwein-Schulz, A., Becher, D., Schweder, T., Bornscheuer, U.T., Hehemann, J.H. (2019), A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan, Nat. Chem. Biol., 15, 803-812