User:Dholston1/sandbox

Article name

Pelvic lipomatosis - https://doi.org/10.1016/j.kint.2016.05.009

This page only has a description/definition of what this condition is along with the population affected by it. There is also a sentence on other things/conditions that are related to it. Since there are really only two sentences in this article, there is a lot that can be added to it. Things that need to be added to this article are why it is associated with hypertension along with if black men are the only ones affected by this condition or just the ones that are most susceptible to it. How many cases of this are diagnosed each year? Additionally, things such as how this condition is diagnosed and whether or not there are any treatment and/or cure options for it can be added to this article. There were some other conditions mentioned in relation to this condition...how are they related? Does one condition lead to the other? Complications from pelvic lipomatosis along with symptoms that patients with this condition may present with can be added.

We will be focusing on the pregnancy-associated malaria wikipedia page since there are more sources of research that can be used.

Maternal and Fetal Outcomes
Another concern for women with PAM is concurrent human immunodeficiency virus (HIV) infection. Women with

Women that are infected with human immunodeficiency virus (HIV) are also at a high risk of having a higher parasite burden within the placenta during pregnancy. This increased parasite burden can show up as increased reporting of symptoms associated with PAM and an increased likelihood of adverse maternal and fetal outcomes. There is also an increased risk of an HIV positive woman developing pregnancy-associated malaria in subsequent pregnancies. Although the exact biological mechanism around how HIV and malaria disease states affect each other, it is thought that there is some interaction between these two in the lymphatic system which can lead to immune system dysfunction.

Prevention and Treatment
Prevention of pregnancy-associated malaria can be done through various antimalarial drugs given either before or during pregnancy. These drugs include chloroquine

One concern with the use of some of these medications for prophylaxis of pregnancy-associated malaria is resistance. In areas that have higher rates of resistance to the antimalarial Sulfadoxine/pyrimethamine, two doses of the drug is effective in reducing maternal parasitemia in women that do not have HIV while more doses are needed to reduce maternal parasitemia in HIV positive women.

Current Research
A vaccine to prevent a pregnancy-associated malaria called PAMVAC is currently undergoing clinical trials. In the first round of clinical trials, it was shown to produced in immune response in the 262 participants receiving the vaccine

Additional genetic testing relating to pregnancy-associated malaria is currently being researched which involved looking at glucose-6-phosphate dehydrogenase (G6PD) which is an enzyme that is responsible for keeping red blood cells protected from being destroyed too soon by things such as foods and medications. The gene for this enzyme is found on the X chromosome which means that women in particular can have G6PD function that is normal, intermediate (which often shows up on lab tests as normal), and deficient. This gene is important in determining if certain antimalarial drugs such as primaquine and tafenoquine can be used since these antimalarial drugs are more likely to cause red blood cell hemolysis, although they would most likely be used after pregnancy for treatment.

Palliative Sedation Peer Review

 * The group's edits to the article do substantially add to the article by adding more information about palliative sedation itself but also some of the history relating to it and its prevalence in other countries. I also think it was very important that there was distinction between palliative sedation and euthanasia. Overall the structure of the article is very balanced and doesn't just focus on one area such as the drugs used for palliative sedation. I'm not sure if this group is done editing or not, but I would like to see a little bit more on the policies regarding this subject that have been approved and what about these policies makes it considered ethical.
 * It looks like this group has achieved its overall goals for improving this page.
 * The points on this page are cited and verifiable with the exception of like two sentences where there was a "citation" next to the information presented, although those particular edits were from someone outside of the group who had previously edited. I think this group has done a very good job at citing the sources they used to contribute to this article since there is a wide variety of sources that were used instead of only a couple articles per person.