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Nanochemistry is the combination of chemistry and nano science. Nanochemistry is associated with synthesis of building blocks which are dependent on size, surface, shape and defect properties. Nanochemistry is being used in chemical, materials and physical, science as well as engineering, biological and medical applications. Nanochemistry and other nanoscience fields have the same core concepts but the usages of those concepts are different.

Nanochemistry was first summarized by Ozin in 1992 as the uses of chemistry synthesis to reproducibly afford nanomaterials from the atom "up", contrary to the nanoengeering and nanophysics approach that operates from the bulk "down". The nano prefix was given to nanochemistry when scientists observed the odd changes on materials when they were in nanometer-scale size. Several chemical modification on nanometer scaled structures, approves effects of being size dependent.

Nanochemistry can be characterized by concepts of size, shape, self-assembly, defects and bio-nano; So the synthesis of any new nano-construct is associated with all these concepts. Nano-construct synthesis is dependent on how the surface, size and shape will lead to self-assembly of the building blocks into the functional structures; they probably have functional defects and might be useful for electronic, photonic, medical or bioanalytical problems.

Silica, gold, polydimethylsiloxane, cadmium selenide, iron oxide and carbon are materials that show the transformative power of nanochemistry. Nanochemistry can make the most effective contrast agent of MRI out of iron oxide (rust) which has the ability of detecting cancers and even killing them at their initial stages. Silica (glass) can be used to bend or stop light in its tracks. Developing countries also use silicone to make the circuits for the fluids to attain developed world's pathogen detection abilities. Carbon has been used in different shapes and forms and it will become a better choice for electronic materials.

Overall, nanochemistry is not related to the atomic structure of compounds. Rather, it is about different ways to transform materials into solutions to solve problems. Chemistry mainly deals with degrees of freedom of atoms in the periodic table however nanochemistry brought other degrees of freedom that controls material's behaviors.

Nanochemical methods can be used to create carbon nanomaterials such as carbon nanotubes (CNT), graphene and fullerenes which have gained attention in recent years due to their remarkable mechanical and electrical properties.

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