User:Dinahcann/sandbox

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The primary function of ACE2 is to act as a counterbalance to the Angiotensin-converting enzyme (ACE). ACE cleaves angiotensin I hormone into the vasoconstricting angiotensin II. ACE2, in turn, cleaves the carboxyl-terminal amino acid phenylalanine from angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and hydrolyses it into the vasodilator angiotensin (1-7), (H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH). ACE2 can also cleave numerous peptides, including [des-Arg9]-bradykinin, apelin, neurotensin, dynorphin A, and ghrelin. ACE2 also regulates the membrane trafficking of the neutral amino acid transporter SLC6A19 and has been implicated in Hartnup's disease. Research in mice have shown that ACE2 is involve in regulation the blood glucose level but its mechanism is yet to confirmed

This has led some to hypothesize that decreasing the levels of ACE2, in cells, might help in fighting the infection. On the other hand, ACE2 has been shown to have a protective effect against virus-induced lung injury by increasing the production of the vasodilator angiotensin 1–7. Furthermore, according to studies conducted on mice, the interaction of the spike protein of the coronavirus with ACE2 induces a drop in the levels of ACE2 in cells through internalization and degradation of the protein and hence may contribute to lung damage. Despise conclusive evidence entry of SARS-CoVID 2 has been associated with triggering diabetes mellitus due to its presence in the pancreatic islets.

Hello, Hi! What's up? Welcome to my sandbox.
I am very nervous about this Wikipedia assignment since this my first time utilizing this website in this way. The fact that a lot of people might see my post is making me anxious but i will do my very best to complete this assignment successfully.

I just want to take this opportunity and say this to 2020, NOT NICE and GOODBYE and finally, to 2021, BE BETTER! This is a test edit so edit away!

Hello,

I can also say that I am nervous about this assignment. I feel like all through high school and college I was told to never use Wikipedia for anything so this should be interesting. I hope we learn and have fun in this class! :D

70.92.15.106 (talk) 15:43, 12 September 2020 (UTC)