User:Dkwillsey/New sandbox

After General Electric dumped polychlorinated biphenyls (PCBs) in the Hudson River from 1947 through 1976, tomcod living in the river were found to have developed an increased resistance to the compound's toxic effects. Scientists identified the genetic mutation that conferred the resistance, and found that the mutated form was present in 99 percent of the tomcods in the river, compared to fewer than 10 percent of the tomcods from other waters.

After General Electric dumped polychlorinated biphenyls (PCBs) in the Hudson River from 1947 through 1976, tomcod living in the river were found to have developed an increased resistance to the compound's toxic effects. The wide spread resistance to the contaminants in the river was believed to be a result of prolonged exposure to high concentrations PCBs and other contaminates. Along with the exposure, the migratory nature of the tomcods mixed with their highly variable breeding strategies is considered a key factor. Scientists identified the genetic mutation that conferred the resistance, and found that the mutated form was present in 99 percent of the tomcods in the river, compared to fewer than 10 percent of the tomcods from other waters.

Wirgin, I., Roy, N. K., Loftus, M., Chambers, R. C., Franks, D. G., & Hahn, M. E. (2011). Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River. Science (New York, N.Y.), 331(6022), 1322–1325. https://doi.org/10.1126/science.1197296

Yuan, Z., Courtenay, S., Chambers, R. C., & Wirgin, I. (2006). Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River. Environmental health perspectives, 114(1), 77–84. https://doi.org/10.1289/ehp.8255=