User:Doc James/Epilepsy

Text: These include the type, number and distribution of voltage- and ligand-gated ion channels, modification of receptors and modulation of gene expression as well as changes in extracellular ion concentration, synaptic plasticity and regulation of transmitter metabolism by glial cells.

Ref: type, number and distribution of voltage- and ligand-gated channels...modification of receptors...Modulating gene expression

Text: Substantial knowledge exists on the cellular and network mechanisms of epilepsy... However, it is unknown under which circumstances the transition from preictal to ictal state occurs

Ref: Although considerable information on cellular and network mechanisms of epilepsy exists, it is still not understood why, how and when transition from interictal to ictal state takes place.

Text: The term seizure threshold is used to describe a certain amount of stimulus necessary to precipitate a seizure.

Ref:seizure threshold, the amount of stimulus necessary to produce a convulsive seizure. 

Text:For instance the activation of single neurons was characterized by microelectrode recordings, brainwide activation patterns were unveiled by functional MRI.

Ref: "Microelectrode recordings have characterized the activation of single neurons and fMRI has unveiled brain-wide activation patterns." opnion peice not about epilepsy

Using scholarpedia and ref broken