User:Donnarahgoshay/Cationic liposome/Bpalanisamy Peer Review

General info

 * Whose work are you reviewing?

Donna Rahgoshay


 * Link to draft you're reviewing
 * https://en.wikipedia.org/wiki/User:Donnarahgoshay/Cationic_liposome?veaction=edit&preload=Template%3ADashboard.wikiedu.org_draft_template


 * Link to the current version of the article (if it exists)
 * Cationic liposome

Evaluate the drafted changes
(Compose a detailed peer review here, considering each of the key aspects listed above if it is relevant. Consider the guiding questions, and check out the examples of what feedback looks like.)

Introduction
Introduction is very succinct and straight which I appreciate. One confusion I had was with the positive charge of the particle. I know that DNA is inherently negatively charged (due to pKa) but why does the liposome have to be positively charged. Are there a lot of cations trapped within the inside sphere?

History
This one is good! I think how the dates are ordered so I can tell the progression of history. I think perhaps you could go into more about exactly what are the differences between cationic and regular liposomes.

Composition
I really like how you explained why liposomes formed in the first place. How does cholesterol help with the rigidity of the memrane? Also I think you should explain that PEGalting the surface of the liposome specifically increases circulation time in blood.

Formation of cationic liposomes for gene delivery
This is awesome! I think a gif or a drawing showing the encapsulation would be nice

Cytotoxicity
I think you can go in depth of why this is cytotoxic. Would PEGlating the surface of the lipid layer help it not be cytotoxic?

Opsonization
I think a picture here would be really helpful!

Overall I think this article is great! I think you should expand on the sentences so that a lay person can understand the material. -Barath