User:Drhyoo/sandbox

Header: Pharmacology

Subheader: Excretion

Due to the large propensity of THC and CBD being hepatically metabolized, a greater proportion of metabolites are excreted via feces than in the urine.

After delta-9-THC is hydroxylated into 11-OH-THC via CYP2C9, CYP2C19, and CYP3A4, it undergoes phase II metabolism into more than 30 metabolites. A majority of these metabolites are products of glucuronidation. Approximately 65% is excreted in feces and 25% in the urine, while the remaining 10% is excreted not in feces or urine. The terminal half-life is approximately 25-36 hours.

CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. The terminal half-life is approximately 18-32 hours.