User:Drlutz/sandbox

Numerous forms of MYLK come from the same original transcript but are then modified postranslation in vivo Thus while there are only 4 different genes for MYLK, post translation modifications account for the major diversity of MYLK amongst different cells.

Mutations and abnormalities in the mylk1 gene result in problems with smooth muscle contraction which can affect breathing and various bowel movements.

Protein kinase C and ROCK Kinase are involved in regulating Calcium ion intake; these Calcium ions, in turn stimulate a MYLK, forcing a contraction. Rho kinase also modulates the activity of MYLK by downregulating the activity of MYLK's counterpart protein: Myosin Light Chain Phosphatase (MYLP). In addition to downregulation of MYLK, ROCK indirectly strengthens actin/myosin contraction through inhibiting Cofilin, a protein which depolymerizes actin stress fibers. Similar to ROCK, Protein Kinase C regulates MYLK via the CPI-17 protein, which downregulates MYLP.