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The International Agency for Research on Cancer (IARC) estimates that globally, 1 in 5 people develop cancer during their lifetime, and 1 in 8 men and 1 in 11 women die from the disease. These new estimates suggest that more than 50 million people are living within five years of a past cancer diagnosis. (IARC, Vol. 15) Ageing populations globally and socio-economic and lifestyle factors remain among the primary factors driving this increase. Breast cancer is the most commonly diagnosed cancer globally, which accounted for 1 in 8 cancers diagnosed and a total of 2.3 million new cases in both sexes combined in 2020 (GLOBOCAN 2020). The disease accounted for a quarter of all cancer cases in women in 2020, and the burden is growing in many parts of the world, particularly in transitioning countries. An estimated 685,000 women died from breast cancer in 2020, which corresponds to 16% or 1 in every 6 cancer deaths in women. By 2020, there were 7.8 million women alive who were diagnosed with breast cancer in the past 5 years, making it the world’s most prevalent cancer. There are more lost disability-adjusted life years (DALYs) by women to breast cancer globally than any other type of cancer. Breast cancer occurs in every country of the world in women at any age after puberty but with increasing rates in later life.

A large geographic variation across countries and world regions exists, with incidence rates ranging from less than 40 per 100,000 females in some Asian and African countries, to over 80 per 100,000 in Australia/New Zealand, Northern America, and in large part of Europe. Smaller geographical variation was observed for mortality; however, transitioning countries continue to carry a disproportionate share of breast cancer deaths relative to transitioned countries. By 2040, the burden of breast cancer is predicted to increase to over 3 million new cases and 1 million deaths every year because of population growth and ageing alone.

The previously insufficient public health response to this development has led to the recent launch of the Global Breast Cancer Initiative (GBCI) in 2020 by the World Health Organization. By engaging global partners and coordinating sustainable efforts to improve outcomes, WHO and collaborators aim to reduce breast cancer mortality by fostering timely diagnosis and adequate treatment and patient management. The initiative focuses on steady escalation in the recognition of breast cancer as a public health priority by governments and stakeholders. The initiative is aimed to provide guidance to governments on how to strengthen systems for diagnosing and treating breast cancer, which in turn is expected to lead to improved capacities to manage other types of cancer. As a foundation to these efforts, a good understanding of global patterns and significant efforts to reduce the disease burden is vital. Till now, significant disparities remain between higher and lower-income countries with the greatest relative increase in breast cancer incidence predicted to be observed in countries classified as "Low or Medium Human Development Index (HDI)" (includes Nepal). GLOBOCAN 2020-2040 prediction shows that low or medium HDI countries will have the greatest relative increases in cancer incidence and mortality by 2040.

Survival rates in high-income countries far exceed of the rates in low-income countries, with 5-year survival exceeding over 80% in most high-income countries as, compared to 66% in India and 40% in South Africa. The high out-of-pocket expenditure, lack of proper diagnostic and treatment facilities poses a significant threat to survival in low-income settings, like in Nepal.