User:Duaa Alshouly

Propionibacterium acnes is an aerotolerant anaerobic Gram positive bacteria, rod-shaped genus from actinobacteria phylum, it is a component of the normal bacterial flora of the skin , commensal and part of the skin flora present on most healthy adult humans' skin, and play an important role in pathogenesis of acne.

Mode of action
After being engulfed and processed by phagocytes, P.acnes induces a strong Th1-type cytokine immune response by producing cytokines such as IL-12, IFN-γ and TNF-α, P.acne binds to TLR2 on monocytes and dendritic cells, leading to activation of the IL-12 promoter, IL-12, TNF-α and IFN-γ are known to be effective antitumor cytokines, P. acnes has been suggested to have antitumor activity.

p.acnes was purified from normal healthy volunteers and cultured in brain-heart infusion medium and injected into dorsal skin of mice at the site where Malignant Melanoma so the tumor size at the end of observation significantly decreased, P.acnes vaccine is a promising candidate as an adjuvant potent therapy and suppressing of Melanoma.