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Cellular Proliferation
The relationship between cellular proliferation and energy metabolism is investigated using cancer Hela cells. Tumor cells need to generate an ample amount of ATP(Adenosine triphosphate)in order to synthesis bioactive compounds like lipids, proteins, and nucleotides for rapid cell proliferation. The generation of this ATP is vital for cell division and other basic function to the regulation of cell volume, solute concentration, and cellular architecture. ATP’s role in the basic function in the cells makes the cell cycle sensitive to changes in availability of mitochondrion derived ATP. In fact, ATP levels differ at various stages of the cell cycle. Additionally reports have shown that cells fail to transition between different stages of the cell cycle under diminished levels of ATP[2]. It is confirmed that interfering with the mitochondrial Oxidative Phosphorylation(OxsPhos) pathway would cause cell cycle arrest since the majority of ATP is produced through OsxPhos pathway. Additionally reports have shown that there is a low energy cell cycle checkpoint that monitors the energy capability before committing to another round of cell division.