User:Dudleydoodog/Trp operon/Dudleydoodog Peer Review

General Information

 * I am reviewing the Trp operon article on Wikipedia.

Review of Trp Operon
The article has a good leading section. It addresses the major points and functions of the operon. However, the paragraph that speaks about repressible negative regulation lacks the explanation of the leader sequence that codes for a small leader peptide with a stop codon. The leader sequence is made up of 4 regions that can form a hairpin structure. The specific locations of the hairpin formation on the 4 regions can either lead to repression or transcription of tryptophan. However, this is further explained in the "Attenuation" sub-section.

The article is up-to-date and relevant on the information presented. The sub-section "Regulation of trp operon in Bacillus subtilis" lacks explanation on the sensing and regulation of tRNA for Trp. The article speaks about how the formation of a termination structure causes for this repression of Trp. However in the article I will be utilizing ,Regulation of the Bacillus subtilis trp operon by an RNA-binding protein by P. Gollnick, they speak about how the Trp opeon contains 'at' operon that creates an Anti-TRAP that could lead to the repress ability of TRAP to bind to the operon's leader RNA. As well as, this article is not organized properly. There is a 'repression' sub-section that should have been placed as a sub-section under the section 'Attenuation'. This section is rather lengthy and should be broken up in explanation of leader sequence, regions on the leader peptide, activation and repression. This would lead to a more cohesive article. The images are rather large for the article and does not include important images such as formation of hairpin structure. Yet the last photo labeled "Mechanism of transcriptional attenuation of trp operon" is extremely helpful for understanding tryptophan operon's repression and transcription. The talk page has not been used since 2016 and many state the information is outdated.

There is a lengthy list of sources cited under 'References'. However, most of the sources cited come from the 1970s to 1980s. Yanofsky, who discovered attenuation efficiency correlation to hairpin structures, writes many of these articles from this time. These are reputable sources. All of the links work and are up-to-date.