User:Duerr045/sandbox

Background
Coiled-coil domain-containing 60 (CCDC60) is a gene located on human chromosome 12 and encodes the coiled-coil domain-containing protein 60 (CCDC60). There are 6 different known protein isoforms, ranging in size from 326-550 amino acids. The largest isoform has a mass of approximately 63 kilodaltons, and contains 14 exons with a 206,000 base pair sequence. There are over 200 orthologs to human CCDC60, and is highly conserved at the amino acid level compared to the chimpanzee (98.9%), pig (82.5%), and mouse (75.7%).

Expression and Function
RNA Sequencing studies suggest expression of CCDC60 appears to be highest in the testes, urinary bladder, lung, prostate, colon, and appendix. The overall function of CCDC60 is unknown. However, it is thought to physically interact with other proteins. Sequence analysis of the CCDC60 promoter suggests binding sites for transcription factors such as c-Myc, STAT5A, HoxA5, TCF3, and Tal1. Genome-Wide Association Studies (GWAS) have identified SNPs in the region of CCDC60 correlated with Alzheimer's Disease, Schizophrenia , and longevity. However, further basic research at the molecular level is required for elucidating the functional importance of CCDC60 in health and disease.