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Commonly Used Inbred Strains
There are many strains of mice used in research, however, inbred strains are usually the animals of choice for most fields. Inbred mice are defined as being the product of at least 20 generations of brother X sister mating, with all individuals being derived from a single breeding pair.

Inbred mice have several traits that make them ideal for research purposes. They are isogenic, meaning that all animals are nearly genetically identical. Approximately 98.7% of the genetic loci in the genome are homozygous, so there are no "hidden" recessive traits that could cause problems. They also have very unified phenotypes due to this stability.

Many inbred strains have well documented traits that make them ideal for specific types of research. These are the top 10 most popular strains according to Jackson Laboratories.

Jackson Labs DO Project

The Jackson Labs DO (Diversity Outbred) project is a mouse breeding program using multiple inbred founder strains to create a genetically diverse population of mice for use in scientific research.

These mice are designed for fine genetic mapping, and capture a large portion of the genetic diversity of the mouse genome.

This project has resulted in over 1,000 genetically diverse mice which have been used to identify genetic factors for diseases such as obesity, cancer, diabetes, and alcohol use disorder.