User:Dydrl31/Bioethics

Purpose and scope
The field of bioethics has addressed a broad swathe of human inquiry; ranging from debates over the boundaries of life (e.g. abortion, euthanasia), surrogacy, the allocation of scarce health care resources (e.g. organ donation, health care rationing), to the right to refuse medical care for religious or cultural reasons. Bioethicists often disagree among themselves over the precise limits of their discipline, debating whether the field should concern itself with the ethical evaluation of all questions involving biology and medicine, or only a subset of these questions. Some bioethicists would narrow ethical evaluation only to the morality of medical treatments or technological innovations, and the timing of medical treatment of humans. Others would broaden the scope of ethical evaluation to include the morality of all actions that might help or harm organisms capable of feeling fear.

 Dolly, a fine Dorset sheep, 

'''Dolly, a Finn Dorset sheep, was born on July 5th, 1996 in United Kingdom. The birth of dolly is a good example of understating bioethics and also it proved that more accurate cloning technology could be used to duplicate a same copy of the animial’s cell. As a result, it makes us to be able to think about human cloning very positively and it has shown a new horizon to biogeneticists in the focus of the public attention. Dolly was important because she was the first mammal to be cloned from an adult cell. Her birth proved that specialized cells could be used to create an exact copy of the animal they came from. This knowledge changed what scientists thought was possible and opened up a lot of possibilities in biology and medicine, including the development of personalized stem cells known as iPS cells.'''

'''However, Dolly was not the first ever cloned mammal. That honour belongs to another sheep which was cloned from an embryo cell and born in 1984 in Cambridge, UK. Two other sheep, Megan and Morag, had also been cloned from embryonic cells grown in the lab at The Roslin Institute in 1995 and six other sheep, cloned from embryonic and foetal cells, were born at Roslin at the same time as Dolly. What made Dolly so special was that she had been made from an adult cell, which no-one at the time thought was possible. '''

Historical Information
 Nuremberg code 

'''Clinical test, human embryo, human genome, population genetics and eugenics. When it comes to theses researches, intrinsic issues about ethic and morality should be considered and it is inevitable. In addition, there is some ethical standards are well-known throughout world and each countries and cities have their own ethical guideline, an international code of conduct and doctrine. Considering all, establishing a concrete standard of studies from the human body was partially based on the history of mankind. As people know, there is not such a thing as a perfect. Everything in the world comes with risk. Nazi eugenics will be a good example of this. It is regarded as important history of medical technology allows us to see that while we have had many failures in altering the human form. The risk of studies from the human body is hyper-notorious and it was noised abroad that World War II ended. What it marked a new era in bioengineering industry was right after an international Nuremberg principle. The plan of human body studies which was executed by Nazism and a need for world war II became an international standard, at the same time, Nuremberg principle proved a catalyst for states to take the national enforcement of international human rights law much more seriously than has hitherto been the case. '''

Ethical Issues in Gene Therapy
Gene therapy involves ethics, because scientists are making changes to genes, the building blocks of the human body. Currently, therapeutic gene therapy is available to treat specific genetic disorders by editing cells in specific body parts. For example, gene therapy can treat hematopoetic disease. There is also a controversial gene therapy called "germline gene therapy", in which genes in a sperm or egg can be edited to prevent genetic disorder in the future generation.

Germline Gene Therapy.

The main purpose of human germline engineering is to enable the scientists to discover the unknown functions of the genes by eliminating specific DNA fragments and observing the consequences in the targeted cell. Also, scientists use Clustered Regularly-Interspaced Short Palindromic Repeats,short for CRISPR technology. It is to fix the gene mutations and to treat or eliminate some diseases that can be passed onto the offspring.

CRISPR technology (Clustered Regularly-Interspaced Short Palindromic Repeats)

'''According to Dr. Doudna, a geneticist, she mentions about CRISPR technology which makes us to be able precisely to change genes such as the word processing program that fixes the typo in a document.. From these unbelievable techniques, people can expect many benefits for their future baby’s sex, height, eye color and even IQ.'''

Designer baby

'''In other words, a type of genetic testing in which doctors are given permission to screen embryos within the human body for any disorders and in hope to select healthy embryos to produce a health baby. '''

Discrimination

'''alternating DNA gives us an opportunity to make superhuman babies that are able to avoid disorders before they are actually born and are capable of alternating DNA. By alternating DNA, People are able to pick traits that can be either kept or discarded based completely on preference of the parents. '''

Ridiculous High Price

'''According to Jean Twenge, who is a professor at Sandigo State University, she mentions that IVF costs around $15,000 a try and is rarely covered by insurance and there will be more extra charges if people want to reduce the risk of miscarriage and abnormalities and plus guaranteeing a boy to complete family is worth about $50,000 or more (Twenge). Furthermore, adding genetic testing and egg donation or a surrogate mother, total prices will be approximately $100,000(Regalado). Considering all, these bio technologies is very costly and procedures are only done amongst those people with lifestyles that are capable of spending money in this type of testing’s.'''

It is unknown how this type of gene therapy affects long-term human development. In the United States, federal funding cannot be used to research germline gene therapy.

'''As is clearly outlined in the latest statement of the ethics committee of the American Society for Reproductive Medicine (ASRM),  however, PGD for sex selection to prevent the transmission of serious sex-linked genetic disease is acceptable and recommended. There is no argument against medically indicated sex selection: the ASRM’s position is that all families have a genuine right to healthy offspring, and they can implement all available technologies to avoid a known genetic disorder. Moreover, in such cases, no preference of one sex to another is expressed based on its supposed value. The ASRM committee advocates that use of PGD for nonmedical sex selection should not be encouraged but does not favor its legal prohibition. The nonmedical reasons are the area of continuing debate.'''

'''Due to patient demand and financial pressures, reproductive endocrinology and infertility physicians may consider providing ethically controversial services. However, it is important to know that practitioners who offer assisted reproductive services are under no legal or ethical obligations to provide nonmedically indicated preconception methods of sex selection . Applying this to the current scenario, Dr. Jones should not feel any legal or ethical obligations to provide reproductive services to the Carters, if doing so conflicts with his own clinical judgment, values, or beliefs. '''