User:DylanCorcoranUMN/sandbox

Introduction:
C11orf49 (Chromosome 11 open reading frame 49) is a protein coding gene that encodes for the protein UPF0705 in humans. Its aliases are FLJ22210 and MGC4707. C11orf49 is heavily associated with promoters GH11J046935 and GH11J046927, with the former playing a larger role in the gene's regulation.

Genome Location:
C11orf49 is located on the short arm of chromosome 11 at band 11.2.

Tissue Expression:
This gene is expressed more in the brain than any other tissue. C11orf49 is also overexpressed in peripheral blood mononuclear cells, which play an important part in the human immune system.

Schizophrenia:
C11orf49 has been shown to be overexpressed in patients who exhibit schizophrenia.

Ovarian Cancer:
C11orf49 was significantly associated with malignant solid tumors leading to ovarian cancer after the integration of HPV 16 at or near the gene.

Sequence Details:
There are a total of 7 isoforms for C11orf49, with isoform 2 being most complete sequence of the protein product with 337 amino acids. Isoform 1 lacks a splice junction towards the 3' end of the protein, resulting in a C-terminal truncated protein when compared to isoform 2. The mRNA contains an in-frame upstream stop codon in the 5' UTR and a polyadenylation sequence in the 3' UTR. The protein contains 9 exons, and has a phosphoserine site at amino acid residue 325.

Orthologs:
NCBI lists 337 orthologs for C11orf49, while Table 1 includes detailed information on 24 orthologs which reach the extremes of C11orf49's evolutionary history and origin.