User:EAGMIL/Osmotic shock/GreyCanary21 Peer Review

General info

 * Whose work are you reviewing?

EAGMIL


 * Link to draft you're reviewing
 * https://en.wikipedia.org/wiki/User:EAGMIL/Osmotic_shock?preload=Template%3ADashboard.wikiedu.org_draft_template
 * Link to the current version of the article (if it exists)
 * Osmotic shock

Evaluate the drafted changes
(Compose a detailed peer review here, considering each of the key aspects listed above if it is relevant. Consider the guiding questions, and check out the examples of what feedback looks like.)

First of all, I'm unsure if it's just not showing as edited in the original article, so disregard if you've already done this, but it may be helpful to add additional sources to the article, maybe from your already-completed bibliography.


 * These should be in there. Hopefully others are able to see them.

For clarity's sake, the addition of MAP Kinase Hog-1 directly after Calcium implies that it's related to calcium, but doesn't specify that relationship (if there is one), so this would be good to clarify.


 * Great insight. MAP Kinase Hog-1 is part of a second messenger pathway that is activated by calcium. I'm working on rewording this so that it is more clear.

The source discussing the potential of an influx of calcium to alter cell permeability is really old - it's from 1988. Is there anything more recent or more detailed about the mechanism of this alteration?

There's no source on discussing Taurine (or at least none that is linked at the end of that statement).


 * The sentence here about Taurine was not my addition. Whoever included it before didn't have a source. I'm thinking it should just be removed. Thoughts?

I'm not sure if you added the figure or not, but additional ideas for figures could include suspected pathway for MAP Kinase Hog-1 or any of the other molecules talked about.


 * I added the figure. MAP Kinase Hog-1 would be great to add in the future.

The sentences at the end are a little confusing; does EXTRACELLULAR ATP activate purinergic receptors, or does its extracellular release decrease the amount of ATP inside the cell that can activate purinergic receptors from the inside? Also, what do these receptors and their Na/K regulation actually do to the cell in osmotic shock. In general, actually, it would be helpful to know as many details as possible as to the mechanisms of these recovery and tolerance mechanisms - maybe these messengers signal increase in translation of Na/K transporters, maybe they just cause increased reaction rates for Na/K transporters. If none of these are true, then maybe specify that the exact mechanism of recovery is unknown but that data shows these messengers are highly correlated with recovery.


 * You're right, more details would be great to include. My one concern is that my article is a stub. I don't want to over inflate these sections. I think I should definitely add some details, but maybe not a ton of information.

Overall, great job! Your article looks awesome!


 * Thank for your review! It was very helpful!

12/11 (Responding to your previous comments)

I'm glad to see you got rid of the Taurine commentary - it seemed a little out of place.

The only other thing that may be interesting to explore (if you ever feel like adding more) would potentially be biotech applications, if there are any.

Otherwise, fantastic job, it looks even better than it did before!