User:EBMLibrarian/sandbox/tetracycline

Use of tetracycline antibiotics can:


 * Discolor permanent teeth (yellow-gray-brown), from prenatal period through childhood and adulthood . Children receiving long- or short-term therapy with a tetracycline or glycylcycline may develop permanent brown discoloration of the teeth.
 * Be inactivated by calcium ions, so are not to be taken with milk, yogurt, and other dairy products
 * Be inactivated by aluminium, iron, and zinc ions, not to be taken at the same time as indigestion remedies (some common antacids and over-the-counter heartburn medicines)
 * Cause skin photosensitivity, so exposure to the sun or intense light is not recommended
 * Cause drug-induced lupus, and hepatitis
 * Cause microvesicular fatty liver
 * Cause tinnitus
 * Interfere with methotrexate by displacing it from the various protein-binding sites
 * Cause breathing complications, as well as anaphylactic shock, in some individuals
 * Affect bone growth of the fetus, so should be avoided during pregnancy
 * Fanconi syndrome may result from ingesting expired tetracyclines.

Caution should be exercised in long-term use when breastfeeding. Short-term use is safe; bioavailability in milk is low to nil. According to the U.S. Food and Drug Administration (FDA), cases of Stevens–Johnson syndrome, toxic epidermal necrolysis, and erythema multiforme associated with doxycycline use have been reported, but a causative role has not been established. https://medlineplus.gov/druginfo/meds/a682098.html

AHFS Patient Medication Information [Internet]. Bethesda (MD): American Society of Health-System Pharmacists, Inc.; c2019. Tetracycline; [updated 2020 Jun 24; reviewed 2017 Aug 15; cited 2024 Mar 12]; [about 5 p.]. Available from: https://medlineplus.gov/druginfo/meds/a682098.html