User:Eal13lanc/sandbox

User:Eal13lanc/Table 5

User:Ahiggs1013/Lactic Acid Cycle/Eal13lanc Peer Review

User:RavynCasey/Lactic acid bacteria/Pmaymicro Peer Review

A rare genetic disorder that affects about one in 35,000 people in the United States. Genetic defects in the enzymes involved in the cycle can occur, which usually manifest within a few days after birth. The recently born child will typically experience varying bouts of emesis and periods of lethargy. Ultimately the infant may go into a coma and develop brain damage. Mutations lead to deficiencies of the various enzymes and transporters involved in the urea cycle and cause urea cycle disorders. If individuals with a defect in any of the six enzymes used in the cycle ingest amino acids beyond what is necessary for the minimum daily requirements, then the ammonia that is produced will not be able to be converted to urea. These individuals can experience hyperammonemia or the buildup of a cycle intermediate.