User:Ebodashamena/sandbox

 Genetic Factors: 

Chromosomal anomalies and genetic mutations account for nearly 10-15% of all male infertility cases.

 Klinefelter Syndrome 

One of the most commonly known causes of infertility is Klinefelter Syndrome, affecting 1 out of 500-1000 newborn males<ref 46="" 47="" na.="" klinefelter="" syndrome="" is="" a="" chromosomal="" defect="" that="" occurs="" during="" gamete="" formation="" due="" to="" non-disjunction="" error="" cell="" division.="" resulting="" in="" males="" having="" smaller="" testes,="" reducing="" the="" amount="" of="" testosterone="" production.="" with="" this="" carry="" an="" extra="" pair="" x="" chromosomes,="" meaning="" they="" have="" pairs="" chromosomes="" compared="" normal="" each="" cell.="" directly="" affects="" sexual="" development="" before="" birth="" and="" puberty="" (links="" learning="" disabilities="" speech="" also="" been="" shown="" be="" affected).="" there="" are="" varieties="" syndrome,="" where="" some="" cases="" may="" chromosome="" all="" cells,="" reffered="" as="" mosaic="" or="" individuals="" cells.="" reduction="" male="" body="" normally="" results="" overall="" decrease="" production="" viable="" sperm="" for="" these="" thereby="" forcing="" them="" turn="" fertility="" treatments="" father="" children. Klinefelter Syndrome is a chromosomal defect that occurs during gamete formation due to a non-disjunction error during cell division. Resulting in males having smaller testes, reducing the amount of testosterone and sperm production. Males with this syndrome carry an extra pair of X chromosomes, meaning they have 47 pairs of chromosomes compared to the normal 46 pairs in each cell. This extra pair of chromosomes directly affects sexual development before birth and during puberty (links to learning disabilities and speech development have also been shown to be affected). There are varieties in Klinefelter Syndrome, where some cases may have the extra X chromosome in all cells, referred to as Mosaic Klinefelter Syndrome, or where individuals have the extra X chromosome in all cells. The reduction of testosterone in the male body normally results in an overall decrease in the production of viable sperm for these individuals thereby forcing them to turn to fertility treatments to father children.

 Y chromosome deletions 

Y chromosomal infertility is a direct cause of male infertility due to its affects on sperm production,occuring in 1 out of every 2000 males Usually affected men show no sign of symptoms other than at times can exhibit smaller teste size. Men with this condition can exhibit azoospermia (no sperm production), oligospermia (small number of sperm production), or they will produce abnormally shaped sperm. This case of infertility occurs during the development of gametes in the male, where a normal healthy male will produce both X and a Y chromosome, affected males have genetic deletions in the Y chromosome. These deletions affect protein production that is vital for spermatogenesis. Studies have shown that this is an inherited trait; if a male is fathered by a man who also exhibited y chromosome deletions then this trait will be passed down. These individuals are thereby “Y-linked”, although daughters are not affected due to the lack of the Y chromosome.