User:Ec2024/FK1012

FK1012 is a dimer consisting of two molecules of FK506 (tacrolimus) linked via their vinyl groups. It is used as a research tool in chemically induced dimerization applications. It serves as a mediator, bringing together two binding domains of FK506. FK506 binding proteins (FKBPs) do not normally form dimers but can be caused to dimerize in the presence of FK1012. Genetically engineered proteins based on FKBPs can be used to manipulate protein localization, signaling pathways and protein activation.