User:Eesssj/Clathrin-independent carrier

The noncaveolar clathrin-independent endocytic (CIE) routes, numbering three, delineate their distinctions through specific regulation by RhoA, Arf6, or Cdc42. Within this pathway, the primary carriers facilitating uptake are the morphologically distinct clathrin-independent carriers (CLICs). Parameters characterizing the CLIC pathway presently encompass dynamin-independent plasma membrane (PM) scission, a notable presence of GPI-anchored proteins, dependence on Arf1 activity, susceptibility to cholesterol depletion, and a substantial contribution to the internalization of cholera toxin B subunit (CTxB) and fluid. CLICs merge with early endosomes after they undergo maturation into the GEEC along with the attachment of Rab5 and EEA-1.