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Yuman Fong is an American surgeon and scientist. He holds the Sangiacomo Chair in surgical oncology and is chairman of the department of surgery at the City of Hope Cancer Center. Fong is best known clinically for his work in the field of hepatobiliary surgery. His work helped establish hepatic resection of colorectal metastases as a safe, effective, and potentially curative option even at stage IV. His most recent work has been to advance the use of ablative and robotic surgery for cancer.

He is editor of the Springer textbook on Image-guided Therapies, and The SAGES Atlas in Robotic Surgery.

Fong has assisted in the design and deployment of many novel surgical tools and gene surgery tools. His group is now working on cell culture and cell-based production of biologics with the goal of making gene therapies, cell therapies, and vaccines affordable and accessible to all. His work in medical engineering has led to his election to the American Institute for Medical and Biological Engineering.

Fong’s early research was on immune activation during cancer or infection. He was part of the group that discovered tumor necrosis factor and helped establish the field of innate immunity. His laboratory focus over the last 15 years has been in the field of gene therapy. His group was the first to administer recombinant viruses into the human bloodstream as a cancer treatment.

He served as the Chair of the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health. He is the founding Editor-in-Chief of Molecular Therapy Oncolytics (Cell Press, journal of ASGCT).

He has co-authored over 1000 articles and 17 textbooks. PLOS Biology, recognized Fong in 2019 as one of the most-cited researchers in the world. Fong was also ranked by Google Scholar as one of the top 1000 most-cited researchers. He has the number-one-cited paper in the history of the American Surgical Association.

Early life
Fong was born on November 2, 1959 in Kowloon. His father Kui Fong was a civil engineer; his mother, Wai Yuet (Tang) Fong, was a seamstress. The Lectureship at the Society of Asian Academic Surgeons honoring parents who have contributed to the success of academic surgeons is named the Kui and Wai Fong Lectureship.

The family emigrated to San Francisco California in 1969.

Education
In 1977, Fong was admitted to and matriculated in the 7-year combined BA-MD program at Brown University. In 1982, he transferred to Cornell University Medical College. This was followed by surgical training at the New York Hospital/Cornell Medical Center under G. Thomas Shires, a research fellowship under Stephen Lowry, and a surgical oncology fellowship Murray Brennan at the Memorial Sloan-Kettering Cancer Center.

Academic career
Fong was appointed an assistant professor to the faculty at Memorial Sloan-Kettering Cancer Center in 1993 with an academic appointment at Weill Cornell Medical Center. In 2000 he was promoted from assistant to full professor with tenure at Cornell University. For over twenty years, he was an attending surgeon at the Memorial Sloan-Kettering Cancer Center (MSKCC), where he held the Murray F. Brennan Chair in Surgery.

In 2014, he left New York to return to California. He was appointed Chairman of the Department of Surgery at the City of Hope Medical Center. There he held the Sangiacomo Family Chair in Surgical Oncology, named for Angelo and Yvonne Sangiacomo

Scientific work
Fong was a post-doctoral fellow along with Kevin Tracey in the laboratory of Stephen Lowry. In collaboration with Lyle Moldawer and Anthony Cerami progress wa made in uncovering the biology of tumor necrosis factor that had just been discovered and the gene sequenced in the Cerami lab. Their work demonstrated that blockade of tumor necrosis factor can prevent sepsis. They also showed that blocking tumor necrosis factor can shut down the entire cascade of cytokines in sepsis and inflammation. They also demonstrated that individual organs contained pools of immune cells that can be the source of cytokines. These studies laid the foundation for anti-TNF therapies (Remicade, Humira, Cimzia, Simponi) now widely used for inflammatory diseases including arthritis.

Collaboration with Howard Federofff led to invention of a method of rapidly producing cancer vaccines using irradiated tumor cells infected with cytokine secreting herpes vectors. Their work also included the first administration of genetically modified viruses into the bloodstream of humans for cancer. Their work included the first non-invasive imaging of viral replication in vivo, and demonstration that oncolytic viruses can be used as diagnostic agents in cancer. Since moving to the City of Hope Medical Center, Fong has collaborated with Nanhai Chen to produce the next generation oncolytic chimeric pox viruses that have an ability to infect and kill almost every tumor type. He has collaborated in producing viruses that can label cancer cells for killing by Car-T cells.

Fong has worked on design and use of a class of AAV gene editing vectors capable of editing with no off-target editing. He is attempting to produce viral vectors and viral vaccines at 10-1000 times more efficient level.

Fong contributed to data that proved that stage 4 metastatic disease to the liver can be cured, and devised a new scoring system (Fong Score) widely used in staging of such hepatic colorectal metastases. Other important contributions in this area include demonstration that liver surgery at high volume centers resulted in improved long-term cancer-related survival, and the first demonstration that systemic chemotherapy is useful as adjuvant after liver resection. More recently, Fong’s group collaborating with Bryan Cleary at the University of California San Diego has highlighted the low level of use of liver resection in California and across the nation. Less than 10% of patients with such disease are offered resection when 40-50% are candidates.

Fong’s work contributed to the demonstration that microwave ablation of liver tumors can be curative. In a collaboration with Serge Evrard (Bordeaux) and Graham Poston (Liverpool, England) they demonstrated that ablations can be combined with resection to extend the number of patients that can be offered potentially curative treatment of liver tumors His group reported the first description of single port laparoscopic hepatectomy. They contributed significant data that robotic resection of liver tumors has superior outcomes. More recently, his group demonstrated that robotic liver surgery can be safely and routinely performed as outpatient surgery

Scientific Service
Fong has been Editor-in-Chief of the American Cancer Society series in Patient Management Problems, the Journal of Interventional Oncology, and Molecular Therapy Oncolytics.

He has served on the Foundation Board of the Society of University Surgeons (SUS), the Board of Trustees of the Society for Surgery of the Alimentary Tract, and the board of directors of the James IV Association of Surgeons. Fong has also served as the treasurer, Vice-president, and president of the International Surgical Group.

He has Chaired the NIH workshop on complementary med (American Society for Parenteral and Enteral Nutrition) 1992; the NIH workshop on Nucleotide Therapies 2012, and The NIH workshop on Gene Therapy, Charting a Future Course 2013. He served as Chairman, Liver Studies Committee for the Commission on Cancer National Cancer Database, 2002-2007. He served as the Chairman, Hepatobiliary Organ Site Committee (1999-2002) and the Upper GI Committee (2002-2004) for the American College of Surgeons Oncology Group. He served as the Chairman, Hepatobiliary Committee for the National Cancer Database 2002-2007. He served as Chair of the Recombinant DNA Advisory Committee (National Institutes of Health) 2011-2013, and on the National DSMB for gene therapy.

He served on the International Advisory Committee of the Princess Chulabhorn Cancer Center in Bangkok, Thailand. He served as the Honorary Overseas Advisor, Surgical Oncology Department of the Cancer Center Welfare Home and Research Institute Kolkata, India.

Honors and awards

 * Stanley Dudrick Research Scholar Prize by American Society for Parenteral and Enteral Nutrition, 1994
 * Election, American Society of Clinical Investigation, 2003
 * Election, American Institute of Medical and Biologic Engineering (AIMBE), 2018
 * Layton F. Rikkers Master Clinician Award, Society for Surgery of the Alimentary Tract, 2019.
 * Flance-Karl Award by the American Surgical Association, 2022.

Personal
Fong is married to Nicole Victoria Bergman, a corporate finance attorney. They have three children, the sports shooters Sandra Fong, Abigail Fong, and Daniellla Fong.

Media
An NBC TV documentary production named “My First Time: The Beijing Olympics” documented life in the Fong household as Sandra and Danielle prepared for the Beijing games. It aired on the opening night of the games and won an Emmy for best sports special 2008. A production entitled “A Day in the Life of Dr. Yuman Fong” won a Telly Award in 2019

Books

 * Blumgart LH, Fong Y. Surgery of the liver and biliary tract.  Churchill Livingstone: London, CD-ROM ed: 1.1, 1997.
 * Clavien P, Fong Y, Lyerly K, Venook A.  Primary and Secondary Liver Tumors: Current and Emerging Therapies.  Blackwell Science Inc.: Malden MA, 1999.
 * Blumgart LH, Fong Y. Surgery of the liver and biliary tract.  W.B. Saunders Co. Ltd.: London, 3rd Edition, 2000.
 * Blumgart LH, Fong Y, Jarnagin W.  Hepatobiliary Cancer.  American Cancer Society Atlas of Clinical Oncology.  B.C.Decker, Hamilton, 2000.
 * Moorse M, Clavien P, Fong Y.  Malignant Hepatic Neoplasms.  Blackwell Science Inc.: Malden MA.  2002.
 * Clavien P, Sarr M, Fong Y.  Atlas of Gastrointestinal and Hepato-Pancreatobiliary Surgery.  Springer: Munich, 2007.
 * Jankowski J, Sampliner R, Kerr D, Fong Y.  Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach.  Blackwell Publishing: Oxford, 2007.
 * Dupuy D, Fong Y, McMullen W.  Interventional Oncology.  Springer, 2013.
 * Fong Y, Dong D.  Hepatobiliary Cancer.  People’s Publishing USA, 2014.
 * Fong Y, Agarwal A.  Gallbladder Cancer.  2014.
 * Fong Y, Giulianotti PC, Lewis J, Groot Koerkamp B. The Modern Operating Room: Changing Role of Imaging and Visualization in Surgery.  Springer, 2014.
 * Fong Y, Kaufmann R, Marchinkowski E, Singh G, Schoelhammer H.  Surgical Emergencies in the Cancer Patient, Springer, 2017.
 * Clavien P, Sarr M, Fong Y.  Atlas of Gastrointestinal and Hepato-Pancreatobiliary Surgery.  Springer: Munich, 2007.
 * Clavien P, Sarr M, Fong Y, Myazaki M.  Atlas of Gastrointestinal and Hepato-Pancreatobiliary Surgery. 2nd Edition.  Springer: Munich, 20014.
 * Fong Y, Woo Y, Lau C, Hyung H, Strong V.  SAGES Atlas of Robotic Surgery, Springer 2018.
 * Fong Y, Brownstein M. Multimodality Heros Versus Neoplasm: The Battle for Homeostadt- A Graphic Novel. 2019.
 * Fong Y, Gamblin TC, Zager J, Han E, Lee B. Textbook of Cancer Regional Therapy: HAI, HIPEC, ILI, HILP, ITH, PIPAC, and Beyond. Springer 2020.