User:Eldijanalilic/sandbox

= AADACL2 =

Ortholog
AADACL2 is found only in mammals, it is not found in any invertebrate. Below is a table with some of the orthologs of the gene

Gene Expression Summary
RNA Sequence Data:

According to NCBI Gene HPA RNA-seq normal tissues, AADACL2 is tissue specific (Figure 1). AADACL2 is expressed at a very high level in skin tissues. It is found at low levels in placenta, esophagus, small intestine and colon (Graph A). It is also found in circular RNA induction during fetal development at higher levels at the intestines at 10 weeks and in the intestines at 20 weeks. And is found at lower levels in: adrenal (10 & 18 & 20 weeks), intestine (17 weeks), lung (10 & 17 & 20 weeks), and in the stomach (10 & 20 weeks)(Graph B). In total RNA found in 20 tissues was highly expressed in the placenta, esophagus, trachea, and lungs. RNA was expressed low in the heart, liver, salivary gland, stomach, thymus, thyroid, and uterus (Graph C). Conditions:

Effect of ZNF750 silencing on differentiated keratinocytes The graph for this study was located all the way to the right. This study’s goal was to understand the molecular cascades governing keratinocyte terminal differentiation. They have found that ZNF750 is strongly activated and essential for keratinocyte terminal differentiation. It can be seen in the graph that when there is the silencing of the ZNF750 gene there is low expression of AADACL2. And when ZNF750 isn’t silenced, AADACL2 is relatively highly expressed.

Localization of AADACL2
The protein AADACL2 is mainly expressed in the skin.

AADACL2 Interactions with Other Proteins
The protein KYNU, NDUFS1, TDO2, FLG2, UQCRFS1, CYC1, NDUFS8, NDUFV1, NDUFS6, and HRG. Most of these proteins have a wide range of functions. Such functions range from catalyzes the cleavage of certain proteins in the cells, whereas other interacting proteins catalyze electron transfer. Some of the interacting proteins also have the function of cell to cell adhesion.