User:Elgrha/Food additive

Safety and regulation
With the increasing use of processed foods since the 19th century, food additives are more widely used. Many countries regulate their use. For example, boric acid was widely used as a food preservative from the 1870s to the 1920s, but was banned after World War I due to its toxicity, as demonstrated in animal and human studies. During World War II, the urgent need for cheap, available food preservatives led to it being used again, but it was finally banned in the 1950s. Such cases led to a general mistrust of food additives, and an application of the precautionary principle led to the conclusion that only additives that are known to be safe should be used in foods. In the United States, this led to the adoption of the Delaney clause, an amendment to the Federal Food, Drug, and Cosmetic Act of 1938, stating that no carcinogenic substances may be used as food additives. However, after the banning of cyclamates in the United States and Britain in 1969, saccharin, the only remaining legal artificial sweetener at the time, was found to cause cancer in rats. Widespread public outcry in the United States, partly communicated to Congress by postage-paid postcards supplied in the packaging of sweetened soft drinks, led to the retention of saccharin, despite its violation of the Delaney clause. However, in 2000, saccharin was found to be carcinogenic in rats due only to their unique urine chemistry.

Food Additive Approval in the United States
The United States Food and Drug Administration (FDA) defines a food additive as “any substance the intended use of which results or may reasonably be expected to result directly or indirectly in its becoming a component or otherwise affecting the characteristics of any food”. In order for a novel food additive to be approved in the U.S., a food additive approval petition (FAP) must be submitted to the FDA. The identity of the ingredient, the proposed use in the food system, the technical effect of the ingredient, a method of analysis for the ingredient in foods, information on the manufacturing process, and full safety reports must be defined in a FAP. For FDA approval of a FAP, the FDA evaluates the chemical composition of the ingredient, the quantities that would be typically consumed, acute and chronic health impacts, and other safety factors. The FDA reviews the petition prior to market approval of the additive.