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35kD major secreted virus protein
In molecular biology, 35kD major secreted virus protein is a family of 35-40 kDa proteins secreted by the members of poxviruses, majorly orthopoxviruses, which are poxvirus immune evasion proteins (PIE domain) with ß-sandwich structure. The common feature of all 35kD major secreted virus proteins is the ability to bind to the CC and CXC classes of the chemokine with relatively high affinity. The 35- 30 kDa chemokine binding protein in orthopoxvirus is called 35-kDa in Orthopoxvirus, whereas the leporipoxvirus expressed counterpart is called T1. As the members of this family mostly bind and inhibit the activity of CC chemokines, they are collectively called viral CC chemokine inhibitor (vCCI), which could be due to the conserved epitopes among the CC chemokines. The encoding genes of vCCI proteins are mostly located at the termini of the virus genome and varied among different species of the poxviruses.

These proteins could be fit into two pfam families (PF02250 and PF03213). As they both contain members of 35kDa proteins as their seeds.