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Tu Youyou received the 2015 Nobel Prize in Physiology or Medicine for her discovery of the semisynthetic derivatives. She conducted research on traditional Chinese medicine and potential contributions to cures for malaria, on the basis of folk medicine and ancient Chinese texts. Before Tu and her team discovered artemisinin, 240,000 compounds had already been tested for use in potential antimalaria drugs, none of which had worked. From reviewing ancient Chinese texts, they found that the compound artemisinin was optimally extracted at lower temperatures, as high temperature water poured over sweet wormwood leaves destroyed essential treatment properties.