User:Emballou/New sandbox

TOX high mobility group box family member 3, also known as TOX3, is a human gene.

The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-boxDNA-binding domains which function to modify chromatin structure. The protein Tox3 is glutamine-rich due to CAG repeats at the C-terminus. TOX3 is located on human chromosome band 16q12.1.

Disease linkage
Mutations in the TOX3 gene are associated with an increased risk of breast cancer. The risk allele rs3803662 is associated with decreased expression of TOX3 and an increase in breast cancer risk.