User:EmilyNorwood/sandbox

Abnormalities in specific circuits of the brain, such as the direct and indirect pathways, can cause obsessive-compulsive deficits and symptoms.


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'''What is the second citation listed for? '''I would strongly encourage you to copy/paste sections of the Biology of obsessive-compulsive order into your sandbox and experiment making edits here. That way when we get to the peer review assignment, your peers will have edits to review from you.''' '''

Peer Review From Nehal Patel
Hey Emily, my name is Nehal Patel and I took the pleasure of reviewing your planned contributions. I was looking at what you proposed, I agree with who I am assuming is Liz. I think I have a general idea where you want to put this but I am unsure. Also another student in our class is also doing something along the lines of Obsessive Compulsive Disorder. I am also reviewing her article. Theres some good information that could potentially help both of you out. I recommend finding her in class and doing some sort of discussion. I feel as though your article could possibly be merged with her's but I think more research and planning needs to be implemented. What I liked about your article is that it is filled with a bunch of big terms that are complex but are linked to other articles which is a good thing. Another thing is that your article went heavy on abbreviations. Maybe expanding some of them could help. Overall good article choice!

Thank you for my review I will definitely look into getting together with the girl who has a similar article. I am having trouble with this and finding something to contribute thanks for the suggestions!

Functional neuroimaging
Functional neuroimaging studies have implicated multiple regions in OCD. Symptom provocation is associated with increased likelihood of activation in the bilateral orbitofrontal cortex(OFC), right anterior PFC, left dorsolateral prefrontal cortex (dlPFC), bilateral anterior cingulate cortex (ACC), left precuneus, right premotor cortex, left superior temporal gyrus(STG), bilateral external globus pallidus, left hippocampus, right insula, left caudate, right posterior cingulate cortex (PCC), and right superior parietal lobule. [8]

I think adding the sentences below will help further explain why the orbitofrontal cortex is important in OCD imaging.
The medial portion of the orbitofrontal cortex connects with the paralimbic-limbic system, including the insular cortex, cingulate gryus, amygdala, and hypothalamus. This area is involved in encoding the representation of the value of an expected outcome, which is used to anticipate positive and negative consequences that are likely to follow a given action.[8]

8. ^ Rotge, Jean-Yves; Guehl, Dominique; Dilharreguy, Bixente; Cuny, Emmanuel; Tignol, Jean; Bioulac, Bernard; Allard, Michele; Burbaud, Pierre; Aouizerate, Bruno (3 March 2017). "Provocation of obsessive–compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies". Journal of Psychiatry & Neuroscience. 33 (5): 405–412. ISSN 1180-4882. PMC 2527721. PMID 18787662.