User:Emmarice11.11/Estrogen-dependent condition

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From the information stated above, an estrogen-dependent condition can be that relating to the differentiation in the steroid sex hormone that is associated with the female reproductive system and sex characteristics. These conditions can fall under the umbrella of hypoestrogenism, hyperestrogenim, or any sensitivity to the presence of estrogen in the body.

Known estrogen-dependent conditions include:


 * mastodynia (breast pain/tenderness)
 * breast fibroids
 * mammoplasia (breast enlargement)
 * macromastia (breast hypertrophy)
 * gynecomastia
 * breast cancer
 * precocious puberty in girls and isosexual precocious puberty in boys
 * melasma
 * menorrhagia
 * endometriosis
 * endometrial hyperplasia
 * adenomyosis
 * uterine fibroids
 * uterine cancers (e.g., endometrial cancer)
 * ovarian cancer
 * hyperestrogenism and associated feminization in males
 * such as in certain conditions like cirrhosis, Klinefelter's syndrome, and aromatase excess syndrome.

Such conditions may be treated with drugs with antiestrogen actions, including selective estrogen receptor modulators (SERMs) such as tamoxifen and clomifene, estrogen receptor antagonists such as fulvestrant, aromatase inhibitors such as anastrozole and exemestane, gonadotropin-releasing hormone (GnRH) analogues such as leuprorelin and cetrorelix, and/or other antigonadotropins such as danazol, gestrinone, megestrol acetate, and medroxyprogesterone acetate.

Homeopathic Therapies
Individuals are entitled to their personalized healthcare path. One of these avenues, when it comes to estrogen-dependent conditions, is herbal medicine. In the realm of herbal medicine, there are numerous herbs that containing a phytoestrogen component. Phytoestrogens are established from plants. These components are not nearly as potent as naturally occurring estrogen, but it is fully capable of synthesizing with the body's estrogen receptors. This means that there is estrogen produced from these herbs, just minimal at that. Some of these phytoestrogen herbs include: licorice (Glycyrrhiza glabra), red clover (Trifolium pratense), soy beans (Glycine max), and alfalfa (Medicago sativa).

Estrogen
Estrogen is a critical sex hormone for women (in conjunction with progesterone). Estrogen is responsible for all different functions in a female body, but is also seen in any gender. These functions are seen in body tracts such as the skeletal system, liver, brain and breasts. There are three different formulations of estrogen: estrone, estradiol, and estriol. These are commonly referred to as E1, E2, and E3, following the listing stated prior. These three formulations have different functions in a women's life. Estradiol (E2) is seen in the reproductive time period. Estriol (E3) is seen primarily during pregnancy. Finally, estrone (E1) is the form the body uses during the postmenopausal period. From all of the three formulations stated earlier, Estradiol (E2) is known to be the strongest. In a normal adult female, the normal range of estrogen in the luteal phase (when ovulation happens, as well as the vascular tissue preparing for the potential zygote ) is 100 pg/ml, in comparison to the proliferative phase (when the uterine lining is thickening ) 40-250 pg/ml.

Menopause
Menopause is the state in which women no longer go through menses. This is seem throughout the years 49-52. This termination of menses is associated with a dramatic drop in estrogen levels. The estrogen levels stated previously dramatically decrease to approximately 20 pg/ml or less when woman enters menopause. Menopause falls under the umbrella of conditions related to hypoestrogenism. There are many symptoms associated with the transition and entrance into menopause.

Treatment
As the human population has evolved and been able to prolong our expiration, more and more women are forced to experience menopause as a side effect. There are a multitude of symptoms associated with menopause such as hot flashes, sleeping difficulties, vaginal atrophy, chills, oligomenorrhea, and many more. Although you cannot treat menopause as a whole, you can attempt to relieve the symptoms during and after menopause.

Hormone Replacement Therapy
As stated above, menopause is seen with an incredibly low amount of estrogen in the body. Because of this, many women can benefit from hormone replacement therapies to make the transition easier. These hormone therapies are referred to as menopausal hormone therapy or MHT. There are systemic and low-dose therapies, and these forms are seen with estrogen and estrogen-progesterone combinations. Systemic therapies include formulations of estrogen and progesterone that include transdermal patches, vaginal rings, and oral hormone therapies. These therapies can help with menstrual irregularities. The low dose therapies can include creams, vaginal rings, or tablets that can assist in symptoms such as vaginal atrophy.

Herbal Remedy
There is relief seen with non-hormonal therapies that can either compliment or replace hormonal therapies. There are numerous herbal medicines that can produce estrogen in the body (much lower rate than synthetic). These medicinals include: dong Maui, red clover, alfalfa, licorice, and black cohosh. At this point, there are minimal adverse effects seen with these herbal medications, but one should consult a doctor prior to consumption to ensure that there are no contradictions in their supplements/medications.

Endometriosis
Endometriosis is an inflammatory condition characterized by the growth and development on the endometrium tissue, found within the uterus, is growing outside of the uterus. Endometriosis is commonly found on the ovaries and other organs near/in the pelvic cavity, but it has also been seen in other organs such as the spleen or lungs. A handful of the symptoms associated with endometriosis are dysmenorrhea, dyschezia, dyspareunia, menorrhagia, and fertility complications. This inflammatory disease shares numerous symptoms with other conditions, so this at times leads to misdiagnoses. Endometriosis can have a confirmed diagnosis with exploratory surgery. This surgery is generally called a laparoscopy.

Treatment
Because endometriosis is an inflammatory condition, there are general OTC (over-the-counter) medications that can assist with pain and the inflammation. This can include medications such as ibuprofen. A different pharamceutical avenue is hormone replacement therapy, but there are also non-parmaceutical options such as accupuncute, massages, and herbal medicine.

Hormone Replacement Therapy
One non-surgical avenue for treatment can be the use of hormone replacement therapies. Estrogen is the main catalyst to endometriosis growth. Once the body is pushed into a hypoesterogenism state to halt the stop of endometrial growth, there are problems resulting from the lack of this sex hormone. This is when hormone replacement therapies are applied. There are risks associated with the use of HRTs for endometriosis, such as the reoccurrence of the growth, but this risk is unknown. It is seen that continuous combined hormone replacement therapy can relieve some symptoms associated with endometriosis. There are numerous options that fall under the continues combined forms, but one of the most well known is the estrogen and progestin combination. This combination allows for the regulation of periods, which can improve the overall state of a patient. Some of these continuous estrogen and progestin combined therapy options are a transdermal patch, oral birth control pills, or a vaginal ring.

Herbal Remedy
If hormone therapy is not something the patient wants to pursue, there are a handful of herbal medicines that have been seen to provide relief. Some herbal medicines have an anti-inflammatory property, and this can decrease the pain associated with endometriosis. Curcumin is an option that falls under the anti-inflammatory medicinals. Curcumin has been seen to decrease the development of endometrial tissue. There are other herbal medicines such as pine bark that can be used in adjunct with oral hormone therapies to provide relief.

Polycystic Ovarian Syndrome
Polycystic ovarian syndrome (PCOS) is seen as numerous cysts developing on the ovaries, and this can be seen with additional symptoms such as oligomenorrhea, hirsutism, acne, weight gain, and fertility issues. PCOS is caused by the ovaries having an excessive amount of male sex hormones. Because of this, PCOS is associated with hyperandrogegism.

Treatment
There are both lifestyle changes and pharmaceutical implementations that can be used in order to improve the symptoms of the patient. Many times, the combination of medications and lifestyle changes can prove to show the best improvement of symptoms, but this is on a case to case basis.

Hormone Replacement Therapy
One of the many pharmaceutical avenues for polycystic ovarian syndrome is the use of oral contraceptives, as these can assist in the hyperandrogegism as well as attempting to regulate the irregularities in menstrual cycles. Another therapy option can be the use of anti-androgens, such as spironolactone, which can decrease the prevalence of androgens in the body, intending to decrease the cyst growth, as well as additional symptoms such as histurism. A newer therapy to the scene is the use of aromatase inhibitors which have the ability to stop the coversion of male sex hormones (i.e. testosterone) into female sex hormones (estradiol) and this can help with the growth of cysts on the ovaries.

Herbal Remedy
There are a handful of herbal remedies that can be used to help in numerous ways. Licorice can be used to decrease the prevalence of androgens in the body. St. John's Wort can be used for mental illness. Peony is also used to decrease the androgens present. Tribulus increases the follicle stimulating hormone in the body. These are just a few of the herbal lifestyle implementations that can be used to relieve the symptoms associated with polycystic ovarian syndrome.