User:Endothelium/sandbox

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Practice Editing Here (Nov 15th in-class Wiki session work)

 * This is a place to practice clicking the "edit" button and practice adding references (via the citation button).

Task:


 * 1) Find a peer-reviewed journal article on PubMed. Practice inserting your citation in the above space using the "cite" tool
 * 2) Choose one "B-level" medical article on Wikipedia from the following list: https://wp1.openzim.org/#/project/Medicine/articles?quality=B-Class&importance=High-Class
 * 3) Practice editing live on Wikipedia by finding a typo in the text or improving the clarity/readability of a sentence by adjusting a few words in a sentence.

Assignment # 3- please post an anonymous copy here!

 * Proposed changes:

Suggestion 1 - to be added to the “Prognosis” section: “In mycosis fungoides cases where affected lymphocytes grow with disease progression (large cell transformation), presence of the transmembrane receptor CD30 in affected cells is associated with improved survival. ”


 * Rationale for proposed changes:

Mycosis fungoides prognosis depends heavily on the cellular milieu – not just sociodemographic factors and upstream predictors. Large cell transformation in some cases is a relevant detail which can inform understanding of disease progression and clinical decision-making.

Therefore, users looking to get a balanced account of disease survival would benefit from information on relevant cellular factors. I included an excellent, recent systematic review and meta-analysis to bolster this claim.


 * Controversy/varied opinions:

To our knowledge, there is no controversy about the effect of CD30+ transformed mycosis fungoides on overall survival from the disease. However, the CD30 in non-transformed disease appears to exert a negative effect on overall survival.


 * Critique of Source:

The article in question appears to be of high quality. The present study is a systematic review and meta-analysis which uses clear criteria to screen and abstract studies for inclusion. Risk of bias assessment is present, clearly defined, and applied to all articles that make it into the final meta-analysis. Conclusions of the article are realistic, only reporting unadjusted and multivariate hazard ratios of death for CD30 expression in transformed disease. Finally, a funnel plot does not suggest any risk of publication bias.


 * Reference:

Antonio Travaglino, MD, Daniela Russo, MD, PhD, Silvia Varricchio, BTD, PhD, Sara Pignatiello, CLT, Antonello Baldo, MD, Marco Picardi, MD, Fabrizio Pane, MD, Massimo Mascolo, MD, PhD, Prognostic Significance of CD30 in Transformed Mycosis Fungoides: A Systematic Review and Meta-Analysis, American Journal of Clinical Pathology, Volume 156, Issue 3, September 2021, Pages 350–355,


 * Template:

Hello, I am a medical student editing this page as part of a class assignment. I have compiled a list of suggestions to improve this article and would appreciate community feedback before proceeding with these edits. Here is a list of my suggestions:

I propose to insert the following content into the Mycosis Fungoides#Prognosis section:

“In mycosis fungoides cases where affected lymphocytes grow with disease progression (large cell transformation), presence of the transmembrane receptor CD30 in affected cells is associated with improved survival. ”

After consulting with MEDMOS, no changes are presently needed to the structure of the article, and the information above can be added to existing sections.

After conducting a literature review, I noticed that prognostic factors were limited only to sociodemographic features, and there was not available information on cellular factor expression and relative survivial. I felt CD30 expression might have been a good addition, to reflect the contemporary work done on survival heterogeneity from mycosis fungoides secondary to biological factors.

1Antonio Travaglino, MD, Daniela Russo, MD, PhD, Silvia Varricchio, BTD, PhD, Sara Pignatiello, CLT, Antonello Baldo, MD, Marco Picardi, MD, Fabrizio Pane, MD, Massimo Mascolo, MD, PhD, Prognostic Significance of CD30 in Transformed Mycosis Fungoides: A Systematic Review and Meta-Analysis, American Journal of Clinical Pathology, Volume 156, Issue 3, September 2021, Pages 350–355.

Thanks, Endothelium (talk) 23:28, 19 November 2021 (UTC)

What to post on the Wikipedia article talk page (part of assignment 3)

 * This will also be covered on Nov 15th in class. Your group should use the below template to share an outline of your proposed improvements (including your new wording and citations). Article talk pages are not places to share your assignment answers. The Wikipedia community will be more interested in viewing your exact article improvement suggestions including where you plan to improve the article (which section), what wording you suggest, and the exact citation (Note: all citations must meet WP:MEDRS)
 * You will not be able to paste citations directly from your sandbox to talk pages (unless you are interested in editing/learning Wiki-code in the "source editing" mode). We suggest re-adding your citations on the talk page manually (using the cite button and populating the citation by pasting in the DOI, website, or PMID). You will have to repeat this process yet again when you edit the actual article live.
 * Talk Page Template: CARL Medical Editing Initiative/Fall 2021/Talk Page Template