User:EnthalpicallyUnfavorable/Evaluate an Article

Which article are you evaluating?
Isothermal titration calorimetry

Why you have chosen this article to evaluate?
Isothermal titration calorimetry (ITC) is a technique used to determine the thermodynamics of a chemical interaction in a solution. The article about ITC in Wikipedia is very short, and lacking of information even in the sections already existing. References are relatively old as well, ranging between 1999 to 2001. My plan is to add references and add information regarding what can be achieved through utilizing ITC technique, along with sections about application. ITC is widely used in different fields of study including biology, materials science, biochemistry, organic chemistry, bioinorganic chemistry, and most importantly for this class, nanoparticle chemistry. ITC has been used to quantify interactions between nanoparticles and biological molecules and also to determine agglomeration of nanoparticles under different environmental conditions (different media, acidity, etc.)

Evaluate the article
This is a short article about isothermal titration calorimetry (ITC). The content of this article is all relevant to the topic and written in a neutral manner. One downside is that the application section is very brief and probably outdated. In terms of references and citations, all the links are still working properly. However, there are only four references as of January 17th, 2023 and a number of citations is missing throughout the page. I am planning to edit this page as a part of my class project, by adding more information and possibly 20 to 30 more references on top of what is already existing.

ITC is widely used in numerous research fields to determine metal binding thermodynamics, surfactant aggregation, enzyme kinetics, etc.. We can probably add more recent references and information for the drug discovery topic as well, as the cited review article is from a decade ago. Additionally, adding how to go around the c-window limitation by conducting competition or chelation experiments, and the importance of reaching injection equilibrium would further strengthen the instrumental section. A method of doing post-hoc analysis by applying basic Hess’ Law to deduce buffer or solvent-free thermodynamics would be beneficial as well, as the observed thermodynamic value contains multiple chemical interactions (ligand-solvent interaction, buffer-proton interaction, etc.).

Lastly, I aim to add a couple sections that are connecting this article to other pages. First of them would be about history: how isothermal titration calorimetry is developed by H. D. Johnston at Brigham Young University, and enhancement of the technique to acknowledge individual contributions and advances in the field. Secondly, limitations of this technique and how it can be used with other techniques, such as differential scanning calorimetry would be useful, if there are any chemists on Wikipedia who want to explore different techniques related or similar to ITC.