User:Epicgenetics/Epigenetics effects of smoking

Lead
Smoking has been found to affect epigenetic regulation of transcription throughout the body's organs. There's already quite an extensive section on DNA methylation in this article, but I would also add DAPK and p16.

There is also lacking information on the effect smoking has on aging in tissues. I would add a section about the premature aging effects smoking has on the body, including information on how smoking accelerates the epigenetic age of lung tissue and airway cells, as well as how smoking cessation can slow this acceleration to non-smoking levels.

This article often portrays the difference between smokers and non-smokers, but I would also like to add references that compare ex-smokers as well, since smoking cessation also has its own epigenetic effects. Perhaps a section on epigenetic reversal effects of cessation and other epigenetic-based therapies. Activation of HDAC2 or SIRT1 could treat COPD or other related diseases based on histone modifications.