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Luke John de Pulford is a human rights campaigner, particularly in the areas of modern slavery and human rights abuses in China. He coordinates the Inter-Parliamentary Alliance on China which he founded with Helena Kennedy, Baroness Kennedy of The Shaws and Iain Duncan Smith. Pulford convened the Coalition for Genocide Response, putting a focus on the Uyghur genocide. He sits as a Commissioner on the Conservative Party Human Rights Commission and advises the World Uyghur Congress.

Activism
Whilst de Pulford has became known for his role in the Hong Kong democracy campaign, such as confronting the pro-establishment Hong Kong politician Junius Ho his human rights campaigns have covered several areas.

Modern slavery
In 2015, John Studzinski joined de Pulford to create Arise, an anti-slavery charity. The group worked with governments, such as Taiwan, on how to eliminate slave labour from supply chains along with global bodies, such as the United Nations, on how to end the trafficking of women in the sex industry. As many victims of trafficking find themselves homeless if they are taken out of modern slavery, de Pulford has worked with MPs to ensure governments enable long term recovery for victims.

Minorities in the Middle East
In 2016 de Pulford ran a campaign which resulted in the first ever declaration of genocide in the UK Parliament regarding the treatment of Yazidis, Christians and other minorities, particularly in Iraq and Syria Mistreatment of Uyghur people

Human and democratics rights in China
the 2019 District Council Elections in Hong Kong. With Mike Pompeo and Tsai Ing-Wen Luke de Pulford was one of seven people cited by the Hong Kong authorities as evidence that media mogul and democracy campaigner Jimmy Lai was colluding with foreign forces.

He formed the Coalition for Genocide response in the Houses of Parliament with Lord Alton and Gregory Stanton to maintain pressure on the Johnson government to prevent and punish mass atrocities against ethnic and religious groups. De Pulford worked with Ewelina Ochab in 2019 to co-found the Coalition for Genocide Response which served at the vehicle for the "Genocide Amendment" which de Pulford drafted with Lord Alton in 2020, then running the campaign to attach it to the 2020 Trade Bill in both the House of Lords and House of Commons. The reform would give UK judges the ability to rule whether there is evidence of genocide in another nation, thence negating a trade agreement. This passed the House of Lords by a majority of 126 votes on 7th December 2020 and was narrowly defeated in the house of Commons on 19th January 2021.

Luke was made a fellow of Hong Kong Watch in February 2020

Launch and growth of I-PAC
In early 2020 de Pulford established the Inter-Parliamentary Alliance on China, described variously as a "game changer in slowing Beijing’s economic and diplomatic advances around the world" and a "nuisance alliance".

De Pulford began a campaign in 2020 with Nathan Law to prosecute British officers serving with the Hong Kong Police Force found to have committed acts of torture during the 2019–20 Hong Kong protests.

Personal
Luke de Pulford is married with three children and lives in London. In 2020 he was awarded the Bene Merenti medal by Pope Francis for his contribution to the anti-slavery movement—the youngest known recipient. His mother is the iconographer Amanda de Pulford.