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The prevalence of Tetralogy of Fallot is estimated to be between 0.03 and 0.04%, which corresponds to approximately 300 to 400 cases per million live births. It accounts for 7-10% of all congenital heart abnormalities, making it the most common cyanotic heart defect. Although males and females were initially believed to be affected equally, more recent studies have shown the Tetralogy of Fallot affects males more than females. About 1 in 100 newborns is diagnosed with a congential heart defect, of which 10% are diagnosed with Tetralogy of Fallot. Genetically, it is most commonly associated with Down syndrome and DiGeorge syndrome. Down syndrome and other chromosomal disorders are known to occur alongside congential heart defects such as Tetralogy of Fallot.