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Pathogenesis
Thymus is a lymphoid organ that develops from the 3rd and 4th pharyngeal pouches

While the pathogenesis of cervical thymus cyst is still unclear, there are two main mechanisms by which this lesion occurs:

It is a benign cause of a cervical mass that only makes up less than 1% of neck masses.
 * 1) Congenital: During the fetal development, the thymus forms from the third branchial pouch which descends to the mediastinum lateral to the thyroid gland. A remnant of this thymic tissue can persist during its descent through the thymopharyngeal duct, and later on become the cause of the lesion. This mechanism has been better supported by the authorities.
 * 2) Acquired: The thymic tissue, mainly the Hassall corpuscles and epithelium reticulum, progressively degenerates and ascends upward to cause the lesion.

Clinical Features
Cervical thymic cyst is a very rare pathology that is often incidentally found due to its asymptomatic nature. The patient usually notices a neck mass that grows slowly which triggers them to see a clinician and be admitted to the hospital. However, it can cause symptoms as it grows in size and compresses on other organs. These symptoms include dyspnea, dysphagia, hoarseness among others. It causes neck swelling. Males are more commonly affected. Most cases occur in the first decade of life, as the thymus tend to atrophy after puberty. This lesion usually affects the left side fo the neck.

The cyst can be small as 1cm or as large as 26cm. The location can vary as well, from the angle of the mandible to as low as the mediastinum.

Diagnosis
Differential diagnosis include other more common cervical masses, such as branchial cyst, cystic hygroma, dermoid-epidermoid cyst.

This lesion is usually not diagnosed before surgery. Pathology must be obtained for an accurate diagnosis.

Ultrasound is used as the first imaging modality, and often shows hypo-echoic, sometimes septated cyst that runs along the sternocleidomastoid muscle.

Other imaging techniques such as CT and MRI can also be used. These are more useful for determining the cyst's relationship to the surrounding structures and planning for the surgery.

The cyst itself contains brown colored fluid. The cyst may be uni- or multi-loculated.

Pathology
The wall of the cyst can have multiple array of pathology. It may have single layered squamous cell to multiple layers of stratified cells. Sometimes the sample includes thyroid or parathyroid tissue. This is thought to be due to the common embryologic origin of thymus and thyroid and parathyroid cells.

Treatment
Surgery is often the treatment of choice for a complete resection through VATS. Because there are important structures surrounding the cyst, such as the carotid sheath, recurrent laryngeal nerve, glossopharyngeal nerve, hypoglossal nerve, and phrenic nerve, the location of the cyst should be carefully established before the operation.

While local resection is usually adequate, thymectomy may be required if there's a suspicion for thymoma or when the cyst is multilocular.

The prognosis for this type of cyst is considered good. Recurrence is very rare in the post-operative period.