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Hospital for Joint Diseases sometimes, early-on, around 1910, was called Hospital for Deformities and Joint Diseases.

Opening in Brownstones
On October 18, 1905, the New York State Board of Charities granted a charter to the Jewish Hospital for Deformities and Joint Diseases. Two months later, at the offices of the Frauenthals' private practice on Lexington Avenue at 61st Street, the Hospital's Trustees elected a President, Emanuel M. Gattle (1858–1933), the owner E.M. Gattle & Co, a large Fifth Avenue jewelry store.

"Purpose: To establish a hospital and Dispensary for medical and surgical treatment of persons afflicted with deformities and joint diseases, without regard to race, creed or color."

The Hospital for Joint Diseases was founded in 1904 by Dr. Henry William Frauenthal, who also was the founding Chairman of the Executive Committee of the Board of Directors.

The hospital first opened by Frauenthal November 1905 in a brownstone at 1919 Madison Avenue, between 123rd and 124th streets. In 1907, the hospital purchased two adjacent brownstones.

In 1922, the Hospital for Joint Diseases, consisted of four brownstones on Madison Avenue, between 123rd and 124th streets, in the middle of the block, which had been converted from residences to wards. Around 1922, the hospital purchased the adjoining houses on both sides of the hospital, allowing for right-of-way rights for the entire block front and several parcels on both sides of the street.

Construction of an 8-story building
Frauenthal spearheaded the construction of a new Hospital for Joint Diseases on Madison Avenue, between 123rd and 124th Streets, which opened in the Spring of 1904, at a construction cost of $1,500,000.

The facility opened in the Spring of 1904 as an eight-story building. When it opened, it was the largest orthopedic hospital in the United States. It had a capacity of 200 free beds and a private pavilion with 75 beds. Each private room had a balcony which was larger than the floor space of the room. The objective was to help patients get sunlight. The lobby was designed similar to that of the Statler Hotel in St. Louis. Facing the entrance was a desk, similar to that of a hotel desk. The hospital was the outgrowth of the Frauenthal Clinic, which was established September 1904 in Manhattan at 558 Madison Avenue (at 56th Street).

HJD moves from Harlem
In 1979, the Hospital for Joint Diseases moved from Madison Avenue and 124th Street. Randolph Guggenheimer (1907–1999), the hospital's only trustee at the time, and Eugene Louis McCabe (1937–1998) spearheaded an effort to insure that hospital services would continue in the old building, which was renamed North General Hospital.

$450,000 expansion in 1934
Charles B. Meyers, architect.

Name changes
NGH was established in response to and as a result of the Orthopedic Institute Hospital for Diseases, formerly the Hospital for Joint Diseases and Medical Center (the "Hospital for Joint Diseases") of which NGH' s facilities were once a part, moving to lower Manhattan and the closure of several other Harlem neighborhood hospitals, including Sydenham Hospital.

On January 28, 1977, the Hospital for Joint Diseases became known as Joint Diseases North General Hospital. On October 27, 1987, the hospital was renamed North General Hospital.

1998 merger
In 1998, two major New York City hospitals — (i) Mount Sinai Medical Center and (ii) New York University Medical Center — merged and was renamed Mount Sinai-New York University Health Services Organization, which maintained two campuses: Mount Sinai Hospital on Fifth Avenue and 100th Street and NYU's Tisch Hospital, on First Avenue at 32d Street. The new organization also included (a) NYU's Rusk Institute of Rehabilitation Medicine, (b) Hospital for Joint Diseases, and (c) New York Downtown Hospital.

2006 merger
In 2006, the NYU Medical Center and the Hospital for Joint Diseases Merged and the Hospital for Joint Diseases was renamed "NYU Hospital for Joint Diseases."

NYU Medical Center and the Hospital for Joint Diseases had been affiliated, beginning in 1986, when NYU School of Medicine established an academic affiliation. The NYU Medical Center started a clinical association in 1994, fused the two orthopaedic departments in 1997, and integrated the rheumatology programs in 2001.

Name change
The NYU Hospital for Joint Diseases was renamed NYU Langone Orthopedic Hospital.

2010 bankruptcy of North General Hospital
In 2010, North General Hospital filed for Bankruptcy under Chapter 11. Rev. Calvin O. Butts III was Chairman of the Board at the time.

Early charity affiliations
In 1917, the Hospital for Joint Diseases became one of five charter members of the Federation of Jewish Philanthropies, the others being Mount Sinai Hospital, Montefiore Hospital for Chronic Diseases, Beth Israel Hospital, and the Lebanon Hospital.

Founder
Henry William Frauenthal, MD (1863–1927), was an orthopedic surgeon. He and his brother, Isaac Gerry Frauenthal (1868–1932), a lawyer, were survivors of the Titanic. In the early hours of March 11, 1927 – years after surviving the Titanic and  years before the Great Crash – Frauenthal committed suicide by jumping from the seventh floor of his Upper West Side apartment at 18 West 70th Street. Frauenthal left the bulk of his fortune to the hospital and, in a footnote to his will, requested that his ashes be scattered from the roof of the hospital on the fiftieth anniversary of its incorporation, "to the four winds." On October 4, 1955, Herman C. Frauenthal, Henry's nephew and closest living relative, toss the ashes by hand over a parapet facing north. Herman C. Frauenthal (1911–1976), at the time, was also a trustee of the hospital.

Miscellaneous news
Actress Sigourney Weaver, in 1987, prepared for a film role at the Hospital for Joint Diseases, in the occupational therapy department. She was researching Dian Fossey who had done landmark research spanning 18 years on gorillas and was, in 1985, murdered in Africa. Fossey had worked as an occupational therapist in Kentucky before working with primates. The film, starring Weaver, Gorillas in the Mist, was released in 1988.

Locations

 * 1921: 1919 Madison Avenue at 124th Street, facing the northeasterly corner of Marcus Garvey Park

Trustees (directors)

 * Harry Centennial Oppenheimer (1889–1962), trustee from 1930 to 1950
 * Norbert Henry Bachmann (1873–1951), trustee from 1933 to 1951, at his death
 * Victor Emmanuel Ratner (1904–1974), business executive and brother of notable physician Herbert Ratner, was trustee from 1950 to ??
 * Herman C. Frauenthal (1911–1976), nephew of the founder, was trustee in 1955; his father Herman C. Frauenthal (1866–1942), was a surgeon
 * Edward L. Bernays (1891–1995), elected to the board in 1958
 * Jacob Joshua Golub, MD (1891–1953), Executive Director from 1929 to 1930. Golub served 22 years at the hospital, until his retirement in 1951. He was also a trustee
 * Louis M. Loeb, Chairman of the Board of Trustees in 1947

Inaugural executives in 1905

 * Emanuel M. Gattle (1858–1933), President from 1905 to 1917
 * Louis Blun, First Vice President
 * Paul M. Herzog, Second Vice President
 * Harry Long, Secretary
 * Louis Frank Rothschild (1869–1957), Treasurer from 1906 to 1957, at his death. Rothschild was founder of the investment banking firm, LF Rothschild. He was also the older brother of Minnie Rothschild (1873–1933), who married Henry W. Frauenthal's brother, Herman C. Frauenthal (1866–1942), also a physician.

Executive directors

 * 1917–19??: Lewis Straus, an associate of the LF Rothschild firm, was President from 1917 to ??
 * 1929–1030: Jacob Joshua Golub, MD (1891–1953), Executive Director from 1929 to 1930. Golub served 22 years at the hospital, until his retirement in 1951.
 * 1952:1968: Abraham Rosenberg was appointed Executive Director in 1952, he had been associated with the hospital since 1929
 * 1968-19??: David H. Ross, MD.

Vice presidents

 * Norbert Henry Bachmann (1873–1951), Vice President from 1942 to 1951, at his death

Director of medicine

 * Milton Lurie Kramer, MD (1906–1965) served a Director of Medicine from 1957 to 1965, at his death.

Founding physicians

 * Jacob Sobel, MD (1871–1954)

Other notable physicians

 * Adolf Lorenz (1854–1946), at the invitation of Frauenthal, traveled from Vienna and began treating patients at the Hospital for Joint Diseases on November 23, 1921.

Notable patients

 * Billy Strayhorn died at the HJD in 1967
 * Monique Von Cleef, infamous dominatrix was placed under arrest in 1967 while recovering at JDH. She was convicted for state lewdness

Annual reports

 * Fifth Annual Report, Hospital for Deformities and Joint Diseases November 1911
 * Eight Annual Report, Dispensary and Hospital Deformities and Joint Diseases November 2014

Heads of the nursing school

 * 1964: Justine Hannan