User:Eva2123/Amorph (gene)

= Amorph (gene) = From Wikipedia, the free encyclopedia Jump to navigationJump to search An amorph is a mutated allele that has lost the ability of the parent allele (whether wild type or any other type) to encode any functional protein. An amorph mutation, or null, is the loss of genetic information for the synthesis of appropriate mRNA.

Depending on the relationships of the parent allele, an amorphous mutant can have various forms of gene interactions.

The term "amorph" was used by Hermann Joseph Muller in 1932.

Amorph alleles are caused not just because of a mutation in the coding sequence, but can also be due to gene regulation problems.

Amorph alleles tend to be recessive, but can be dominant to wild type phenotypes. An example of a disease caused by an amorph allele is Rhnull disease. The disease is caused by a mutation in the RH gene; therefore, silencing transcription, specifically at the 1p36-p34 locus.

See also[edit]

 * Allele
 * Gene mutation
 * Muller's morphs
 * Rhnull disease
 * Transcription
 * Recessive
 * Dominance

References[edit]

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