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Staphyloccus pseudintermedius has zoonotic potential as it has been found in humans that live with companion animals in the same household. S. pseudintermedius is not a normal commensal bacterium found in humans, however it is capable of adapting to the human microflora and has become increasingly more common. People whom are at the highest risk for contracting this pathogen are pet owners and veterinarians due to their higher contact with dogs and to a lesser extent cats. The most common place of colonization in the human body is within the nasal cavity and from here, the bacteria can cause infections. S. pseudintermedius infections in a human host have been known to cause endocarditis, post-surgical infections, inflammation of the nasal cavity (rhinosinusitis) and catheter-related bacteremia. Staphyloccus pseudintermedius becomes established in a human-wound, it has the ability to form antibiotic resistance biofilms. Mechanisms of biofilm resistance of S. pseudintermedius are likely multifactorial and may help to establish infections in humans.

There is an increasing prevalence of antibiotic resistance, specifically to methicillin of Staphyloccus pseudintermedius which makes it more challenging to treat when habituating a human host. Veterinary dermatologists are exposed to animals with skin and soft infections that commonly posses MRSP (methicillin‐resistant Staphylococcus pseudintermedius). Veterinarians have been found to be colonized with MRSP but not MSSP (methicillin‐susceptible S. pseudintermedius). Treatment of human MRSP infections is done with antibiotics and these should not be used for treatment in animals. Oral antimicrobial treatment for active infection is commonly done with the use of mupirocin, linezolid, quinupristin, rifampicin or vancomyocin are possible treatments. Hand washing, sterilizing equipment and hygiene practices should be implemented to decrease the spread of Staphylococcus infections.