User:Ewickstrom/Eric Wickstrom

Eric Wickstrom, Ph.D. (December 21, 1946) is a Professor of Biochemistry and Molecular Biology at Thomas Jefferson University in Philadelphia.

Prof. Wickstrom and his coworkers design nuclear medicine genetic probes to image and measure the activity of cancer genes in suspect masses from outside the body. The group also designs magnetic resonance genetic probes and near infrared fluorescence genetic probes for external imaging.

On the therapeutic side, Prof. Wickstrom and his coworkers design genetic therapy agents including mRNA cutters, transcription blockers, and beta particle radiohybridization agents. To detect circulating tumor cells in a drop of blood in less than a minute, the group is developing carbon nanotube-antibody microjunctions that will function in handheld devices to reach underserved populations.

In collaboration with orthopaedic surgeons seeking to protect implants from bacterial biofilms, Prof. Wickstrom and his coworkers design permanent antibiotic-titanium and antibiotic-polymer surfaces.

Education

·	1964-1968: Bachelor of Sciences with Honor, Biology, California Institute of Technology, Pasadena, California	mentor: Dr. Jerome Vinograd

·	1968-1972: Doctor of Philosophy, Chemistry, University of California, Berkeley, California		mentor: Dr. Ignacio Tinoco ·	1973-1974: Research Associate, Chemistry, and Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 	mentor: Dr. Michael Yarus

Books

·	Wickstrom, E., ed. (1998) Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors, Marcel Dekker, New York, ISBN 0-8247-0085-6

·	Wickstrom, E., ed. (1991) Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS, Wiley-Liss, New York, ISBN 0-471-56880-5

Selected Chapters and Reviews

·	Wickstrom, E., and Thakur, M. L. (2009) Molecular Imaging. In: Sauter, E. R., and Daly, M. B., eds., Breast Cancer: Prevention and Early Detection, Springer, Boston, in press

·	Wickstrom, E., and Thakur, M. L. (2006) Imaging cancer gene activity in patients from outside the body. Biotechnology Healthcare 2(2):45-48

·	Tian, X., Chakrabarti, A., Amirkhanov, N., Aruva, M., Zhang, K., Mathew, B., Cardi, C., Qin, W., Sauter, E. R., Thakur, M. L., and Wickstrom, E. (2005) External imaging of CCND1, MYC and KRAS oncogene mRNAs with tumor-targeted radionuclide-PNA-peptide chimeras. In El-Deiry, W., ed., Tumor Progression and Therapeutic Resistance, Annals of the New York Academy of Sciences, 1059:106-144

·	Efimov, V., Chakhmakhcheva, O., and Wickstrom, E. (2005) Synthesis and application of negatively charged PNA analogues. Nucleosides, Nucleotides, and Nucleic Acids 24(10):1853-1874 ·	Smith, J. B., and Wickstrom, E. (2000) Preclinical antisense DNA therapy of cancer in mice. In Phillips, M. I., ed., Methods in Enzymology 314, Antisense Technology, Part B, Academic Press, Orlando FL, 537-580

Selected Scientific Papers

·	Shao, N., Wickstrom, E., and Panchapakesan, B. (2008) Single nanotube-antibody biosensor arrays for detection of circulating breast cancer cells. Nanotechnology 19(October):465101

·	Amirkhanov, N.V., Dimitrov, I., Opitz, A.W., Zhang, K., Lackey, J.P., Cardi, C.A., Lai, S., Wagner, N.J., Thakur, M.L., and Wickstrom, E. (2008) Design of (Gd-DO3A)n-polydiamidopropanoate-peptide nucleic acid-D(Cys-Ser-Lys-Cys) magnetic resonance contrast agents. Biopolymers 89(12):1061-1076

·	Cesarone, G., Edugupanti, O.P., Chen, C.-P., and Wickstrom, E. (2007) Insulin receptor substrate 1 knockdown in human MCF7 estrogen receptor-positive breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analog of insulin-like growth factor 1. Bioconjugate Chemistry 18(6):1831-1840

·	Tian, X., Aruva, M.R., Zhang, K., Cardi, C.A., Thakur, M.L., and Wickstrom, E. (2007) PET imaging of CCND1 mRNA in human MCF7 estrogen receptor-positive breast cancer xenografts with an oncogene-specific [64Cu]DO3A-PNA-peptide radiohybridization probe. Journal of Nuclear Medicine 48(10):1699-1707

·	Edupuganti, O.P., Antoci, V., Jr., King, S.B., Jose, B., Adams, C.S., Parvizi, J., Shapiro, I.M., Zeiger, A.R., Hickok, N.J., and Wickstrom, E. (2007) Vancomycin covalently bound to Ti6Al4V pins provides longterm inhibition of Staphylococcus aureus colonization. Bioorganic & Medicinal Chemistry Letters 17(10):2692-2696

·	Vorobjev, P.E., Smith, J.B., Pyshnaya, I.A., Levina, A.S., Zarytova, V.F., and Wickstrom, E. (2003) Site-specific cleavage of RNA and DNA by complementary DNA-bleomycin A5 conjugates. Bioconjugate Chemistry 14(6):1307-1313

·	Cleaver, S.H. and Wickstrom, E. (2000) Transposon Tn7 gene insertion into an evolutionarily conserved human homolog of Escherichia coli attTn7. Gene 254(1-2):37-44

·	Smith, J.B. and Wickstrom, E. (1998) Antisense c-myc and immunostimulatory oligonucleotide inhibition of tumorigenesis in a murine B-cell lymphoma transplant model. Journal of the National Cancer Institute 90(15):1146-1154 ·	Huang, Y., Snyder, R., Kligshteyn, M., and Wickstrom, E. (1995) Prevention of tumor formation in a mouse model of Burkitt's lymphoma by 6 weeks of treatment with anti-c-myc DNA phosphorothioate. Molecular Medicine 1(6):647-658 ·	Wickstrom, E., Bacon, T.A., and Wickstrom, E.L. (1992) Down-regulation of c-Myc antigen expression in lymphocytes of Em-c-myc transgenic mice treated with anti-c-myc DNA methylphosphonates. Cancer Research 52(24):6741-6745 ·	Wickstrom, E.L., Bacon, T.A., Gonzalez, A., Freeman, D.L., Lyman, G.H., and Wickstrom, E. (1988) Human promyelocytic leukemia HL-60 cell proliferation and c-Myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-MYC mRNA. Proceedings of the National Academy of Sciences USA 85(4):1028-1032