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Scola worked as a Hollywood screenwriter for a multitude of prominent production companies during the studio era, such as Warner Bros., Paramount Pictures and 20th Century Fox. Scola’s career took place during the transition from unregulated Pre-Code films to the implementation of the Motion Picture Production Code, and was frequently involved in writing screenplays that were deemed too controversial by the Motion Picture Association of America. Three of Scola’s films were included in the Forbidden Hollywood film series, including Baby Face, Female and Midnight Mary.

Career
Kathryn Scola wrote a number of her scripts in collaboration with other Hollywood screenwriters, the most frequent being Gene Markey. In 1933, Scola and Markey wrote the screenplay for Baby Face, starring Barbara Stanwyck, which underwent various revisions due to Production Code regulations and was rereleased in a Post-Code edition. Scola and Markey also worked together on the 1933 film Female, which dealt with themes of sexual harassment. During the same year, Scola and Markey worked on the screenplay for the controversial Pre-Code film Midnight Mary, initially titled 'Nora' and first attempted by Anita Loos, which death with themes relating to the Spanish Civil War. In October 1936, three months after the start of the war, Scola and Markey presented their script for Midnight Mary to Darryl F. Zanuck, the production head at Warner Bros. studio.

In 1935, Scola co-wrote the screenplay for the film The Glass Key, an adaptation of the Dashiell Hammet novel, with writer Kubec Glasmon. In 1937, Scola and Darrell Ware collaborated to write the script for the film Second Honeymoon, directed by Walter Lang. In 1943, at the outset of the Second World War, Scola and Julien Josephson wrote the script for Happy Land, a 20th Century Fox production that was meant to prepare audiences for the losses of the war. During 1946, Scola wrote a screenplay for the Max Ophüls 1949 American film noir Caught, which would eventually be rejected by the censorship board due to what was deemed questionable material. Scola’s script was revised by various writers and eventually abandoned, leading to the final screenplay by playwright and screenwriter Arthur Laurents. Scola and Julien Josephson also worked together on the original screenplay for “In Times Like These” in 1956, a teleplay included in the anthology series The 20th Century Fox Hour.