User:Ewingdo/sandbox/list of cardiology clinical trials


 * Early versus Late Intervention Trial with Estradiol (ELITE) -

Acute Coronary Syndrome / Coronary Artery Disease

 * ACCOAST - determine if pretreatment with prasugrel is superior to treatment with prasugrel selectively after percutaneous coronary intervention.
 * ASCERT - observational study comparing survival in patients undergoing PCI vs CABG.
 * Aspirin and heparin in acute unstable angina -
 * ATLAS-ACS-2-TIMI-51 -
 * AUGUSTUS - Apixaban and antiplatelet therapy for Afib + CAD
 * BARI -
 * BARI-2D -
 * BASKET-PROVE - Drug-eluting coronary stents vs bare-metal stents
 * CADILLAC -
 * CAPRIE -
 * CHARISMA -
 * CLARITY-TIMI 28 - Clopidogrel + aspirin and fibrinolysis in STEMI
 * COMMIT - Beta-blockers in patients with MI
 * COURAGE - PCI vs medical therapy for stable CAD
 * CURE - Clopidogrel + aspirin in NSTEMI
 * CURRENT-OASIS-7 -
 * DANAMI-2 - PCI vs fibrinolysis in MI
 * DIGAMI -
 * DIGAMI-2 -
 * EPHESUS -
 * ESPRIT
 * FAME -
 * FAME-2 -
 * FAME 3 -
 * FREEDOM - Multivessel CAD in diabetics
 * GISSI-1 -
 * GISSI-2 -
 * GISSI-3 -
 * GISSI Prevention -
 * GUSTO - Thrombolysis for acute myocardial infarction
 * HEAT-PPCI -
 * HOPE - ACE-I effect on CV outcomes
 * HORIZONS-AMI -
 * ISCHEMIA -
 * ISIS-1 -
 * ISIS-2 -
 * ISIS-4 -
 * MRFIT - randomized primary prevention trial to test the effect of a multifactor intervention program on mortality from coronary heart disease. Men were randomly assigned either to a special intervention program consisting of stepped-care treatment for hypertension, counseling for cigarette smoking, and dietary advice for lowering blood cholesterol levels, or to their usual sources of health care.
 * NORDISTEMI -
 * OASIS-5 -
 * OASIS-6 -
 * [[ONTARGET] -
 * ORBITA -
 * PIONEER AF-PCI - Rivoraxaban and antiplatelet therapy for Afib + CAD
 * PLATO - Ticagrelor vs clopidogrel in ACS
 * PRAMI -
 * PRODIGY -
 * RITA-3 -
 * RIVAL -
 * SYNTAX - PCI vs CABG for severe CAD
 * TACTICS-TIMI-18 -
 * TAPAS -
 * TIMACS - Early vs delayed PCI in ACS
 * TIMI score study -
 * TRILOGY-ACS -
 * TRITON-TIMI 38 - Prasugrel vs clopidogrel in ACS

Hypertension

 * ACCOMPLISH - Benazepril + amlodipine for hypertension
 * Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) - ACE-Is, CCBs, and thiazides for hypertension
 * DASH - Diet for hypertension
 * DASH-Sodium -
 * HYVET - Managing hypertension in the elderly
 * IDNT - ARBs for diabetic nephropathy
 * LIFE -
 * OmniCarb -
 * OmniHeart -
 * PROGRESS -
 * SHEP - Benefit of treating HTN to reduce stroke risk
 * Systolic Blood Pressure Intervention Trial (SPRINT) - Intensive BP control
 * Symplicity HTN-2 -
 * Symplicity HTN-3 -
 * Syst-Eur -
 * TOHP 1 - Non-pharmacological interventions for BP control
 * VALUE -

Lipids

 * LRC-CPPT -
 * SEAS -
 * ARBITER-6 -
 * SHARP -
 * Coronary Drug Project -
 * FATS -
 * HPS2-THRIVE -
 * VA-HIT -
 * FIELD -
 * CLEAR -
 * ODYSSEY OUTCOMES -
 * HOPE-3 -
 * LIPID -
 * AVERT -
 * LIPS -
 * ALLIANCE -
 * TNT -
 * AFCAPS/TexCAPs -
 * A to Z -
 * ACCORD -
 * AIM-HIGH (trial) - Niacin for HDL levels.
 * ALLHAT-LLT -
 * ASCOT-LLT/LLA -
 * ASTEROID -
 * AURORA -
 * CARE -
 * CARDS trial -
 * CORONA trial -
 * ENHANCE trial -
 * Helsinki Heart Study - landmark clinical trial conducted to assess the efficacy of gemfibrozil in reducing the incidence of coronary heart disease in middle-aged men with dyslipidemia.
 * HDL-Atherosclerosis Treatment Study (HATS) - a double-blind trial that studied people with coronary heart disease and compared a combination of simvastatin and niacin with antioxidant vitamin therapy.
 * Heart Protection Study - a randomized controlled trial that studied the cholesterol-lowering drug simvastatin and vitamin supplementation in people at risk of cardiovascular disease.
 * IDEAL -
 * IMPROVE-IT trial -
 * JUPITER trial - clinical trial aimed at evaluating whether statins reduce heart attacks and strokes in people with normal cholesterol levels.
 * LIPID -
 * MEGA -
 * METEOR -
 * MIRACLE -
 * PROSPER -
 * PROVE-IT TIMI 22 - randomized, double-blind clinical trial that compared intensive vs. moderate-dose statin therapy immediately after a heart attack.
 * REVERSAL -
 * SATURN trial -
 * Scandinavian_Simvastatin_Survival_Study (4S) - clinical trial that studied the use of the cholesterol-lowering drug simvastatin in people with moderately raised cholesterol and coronary heart disease.
 * SEARCH -
 * SPARCL -
 * West of Scotland Coronary Prevention Study (WOSCOPS) - randomized, double-blind, placebo-controlled clinical trial that compared the cholesterol-lowering drug pravastatin in patients with no previous history of a heart attack.

Heart Failure

 * A-HeFT - Isosorbide dinitrate and hydralazine for heart failure
 * BEAUTIFUL -
 * CARRESS-HF -
 * CHARM -
 * CIBIS-II -
 * COMET -
 * CONSENSUS - ACE-Is for heart failure
 * COPERNICUS - Carvedilol for heart failure
 * DAPA HF - Dapagliflozin in CHF
 * DIG -
 * DOSE - Diuretics for acute heart failure
 * EMPEROR Reduced - Empagliflozin in CHF
 * EMPHASIS-HF - Eplerenone for heart failure
 * HARPS -
 * HEARTMATE II - LVAD for advanced HF
 * I-PRESERVE -
 * Multicenter Automatic Defibrillator Implantation Trial (MADIT) - implantable cardioverter defibrillator (or ICD) trials which investigate whether prophylactic ICD therapy in moderately high-risk coronary patients (in addition to conventional therapy) would significantly reduce death compared with patients treated with conventional therapy alone.
 * MADIT II - ICD for heart failure with reduced EF
 * MADIT CRT - CRT-D for heart failure with reduced EF
 * MERIT-HF - Metoprolol for heart failure
 * PARADIGM-HF - Sacubitril-valsartan for CHF
 * RALES - Spironolactone for heart failure
 * REMATCH -
 * SAVE - ACE-Is for LV dysfunction
 * SCD-HeFT -
 * SHIFT -
 * SOLVD -
 * STITCH -
 * Val-HEFT - ARB for heart failure
 * WARCF -

Arrhythmias

 * ACUTE - TEE for Afib cardioversion
 * AFFIRM - Rate control vs rhythm control for Afib
 * AFIRE - Rivaroxaban for Afib + stable CAD
 * APAF -
 * ARISTOTLE - Apixaban vs warfarin for Afib
 * ATHENA -
 * AUGUSTUS - Anticoagulation + DAPT for CAD
 * BRIDGE - Perioperative anticoagulation bridging for Afib
 * [[Cardiac Arrhythmia Suppression Trial[[ (CAST) - double-blind, randomized, controlled study designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality.
 * CAST II -
 * CASTLE AF -
 * Early AF -
 * EAST AFNET -
 * LAAOS 3 -
 * MANTRA-PAF -
 * PALLAS -
 * PINNACLE FLX -
 * PIONEER AF-PCI Rivaroxaban + DAPT for Afib + CAD
 * PRAGUE 17 -
 * PREVAIL -
 * PROTECT AF -
 * RACE-II -
 * RAFT-AF -
 * RE-LY -
 * ROCKET-AF -
 * SPAF -
 * SPAF-III - Warfarin dosing for Afib
 * SPAF-II -
 * START AF / STAR AF 2 -
 * STOP AF -
 * SWISS APERO -
 * ThermoCool-AF -

Valvular diseases

 * PARTNER A – TAVR in high-risk patients
 * PARTNER 3 – TAVR in low-risk patients
 * COAPT – Transcatheter mitral valve repair
 * EASE – Surgery for infective endocarditis