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= Dorrigocin A = Dorrigocin A is the inhibitor of the carboxyl methyltransferase, an enzyme involving in the post-translational modification of Ras-related protein. The post-translational modification of Ras-GTPases is a significant process for cellular processes for its important role in proper cell-membrane localization. When the Ras protein is accurately attached to the cell membrane, the protein can proceed in various cellular processes. Dorrigocin A is in the class of Glutarimide-containing polyketides; that is a family of more than 50 compounds all isolated from Streptomyces species and the compounds shared different bioactivities. The Dorrigocin A is derived from iso-migrastatin which was yielded by mgs PKSs core architecture.

Biosynthesis
In module 1 and 2, the characteristic glutarimide moiety will be introduced and it is convinced that the biosynthesis of glutarimide is initiated by Type II ACP/PCP MgsC accompanying with its respective homolog. In module 1, a double bond was formed, and the double bond experience a Michael addition reaction with a malonyl-CoA. The following process of cyclization will generated the glutarimide structure and its functionality. In the following three module, two a-methyl groups were introduced. mgs PKSs was used for the biosynthesis of Dorrigocin A. After module 10, the intermediate was hydroxylated by MgsK and the OH group that was hydroxylated was later methylated by MgsJ and an enoyl reduction reaction also taken place by MgsI. Dorrigocin A was formed followed the reaction where the isomigrastatin react with water.