User:Farres Kamel/Malaria vaccine

Farres Kamel (fk244)

Kathleen Hefferon - BIOMI 1110

May 6, 2024

Difficulties in developing a malaria vaccine
Creating a malaria vaccine is a difficult task. Throughout its life cycle, the malaria parasite is a complicated creature that goes through several phases. Furthermore, a vaccination must be effective against every strain of the malaria parasite, as there are numerous variations.

Future of malaria vaccinations:
Work on developing fresh, enhanced vaccines is still ongoing. Vaccines that employ genetically modified parasites and those that target the parasite's sexual stages are among the most promising new strategies.

RTS,S Clinical Trials Partnership. (2015). Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. The Lancet, 386(9988), 31-45

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(03)15267-1/fulltext.

"A phase 3b trial of the R21/Matrix-M malaria vaccine in seven African countries" ( https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2821%2900943-0/fulltext ) - This article details a large-scale clinical trial for the R21/Matrix-M vaccine.

The Bill and Melinda Gates Foundation - Malaria ( https://www.gatesfoundation.org/our-work/programs/global-health/malaria ) - Provides information on the foundation's support for malaria vaccine research and development.

"Safety and immunogenicity of a multistage PfSPZ-CVac malaria vaccine in healthy adults: a phase 1, double-blind, randomized controlled trial" ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054918/ ) - This article explores a different vaccine candidate targeting multiple stages of the malaria parasite.

Malaria Vaccine Initiative (MVI) ( https://www.malariavaccine.org/ ) - Offers updates on various malaria vaccine candidates and development efforts.

Cochrane Database of Systematic Reviews - Vaccines for preventing malaria ( https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013398.pub4/full ) - This review summarizes the evidence on various malaria vaccine approaches.

World Health Organization (WHO) - Malaria ( https://www.who.int/news-room/fact-sheets/detail/malaria ) - Provides information on malaria burden, prevention strategies, and the WHO's recommendations on malaria vaccines