User:Fatoomaq

 The Relationship between TATA box and Nucleosome 

Most of the regulation are occur around the nucleosome which is chromatin basic repeating unit. The nucleosome is prepared by wrap 147 base pair of DNA less than two times around octameric protein core. Nucleosome precipitation happens during DNA replication .To start gene transcription in eukaryotes needs multi protein complex (PIC)1 that can help RNA polymerase to a promoter. At many stimulus, binding TATA box to TBP is the most crucial step in PIC assembly. In C- terminal domain TBP consists of 180-residue that is all Eukaryotes 80% are identical in sequence while in N- terminal domain there are different in length and sequence.