User:Filll/quotemine

Jerry Coyne, of the Department of Ecology and Evolution at the University of Chicago, arrives at an unanticipated verdict: "We conclude--unexpectedly--that there is little evidence for the neo-Darwinian view: its theoretical foundations and the experimental evidence supporting it are weak."

Although a few biologists have suggested an evolutionary role for mutations or large effect (Gould 1980; Maynard Smith 1983: Gottlieb, 1984; Turner, 1985), the neo-Darwinian view has largely triumphed, and the genetic basis of adaptation now receives little attention. Indeed, the question is considered so dead that few may know the evidence responsible for its demise. Here we review this evidence. We conclude--unexpectedly--that there is little evidence for the neo-Darwinian view: its theoretical foundations and the experimental evidence supporting it are weak, and there is no doubt that mutations of large effect are sometimes important in adaptation. We hasten to add, however, that we are not "macromutationists" who believe that adaptations are nearly always based on major genes. The neo-Darwinian view could well be correct. It is almost certainly true, however, that some adaptations involve many genes of small effect and others involve major genes. The question we address is, How often does adaptation involve a major gene? We hope to encourage evolutionists to reexamine this neglected question and to provide the evidence to settle it.


 * http://bostonreview.net/BR22.1/coyne.html
 * http://www.rae.org/notracist.html
 * http://www.americanhumanist.org/humanism/suckered.html