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Sir 'James Leyburn (c1490-20 August 1548) was MP for Westmorland in 1542 and 1545. He was a Justice of the Peace for Westmorland, Escheator of Cumberland and Westmorland and commissioner of the survey of the monasteries of Lancashire in 1536.

Family
Leyburn was the son of Thomas Leyburn, of Conswick, Westmorland, and Margaret, daughter of Sir John Pennington, of Muncaster Castle, Cumberland. He married twice: to Eleanor, daughter of Sir Thomas Curwen, of Workington, Cumberland, and to Helen, daughter of Thomas Preston, of Preston Patrick, Westmorland. His daughte Anne married William Stanley, Lod Monteagle, and his daughter Elizabeth married twice, to Thomas, Lord Dacre, and secondly to Thomas Howarrd, 4th Duke of Norfolk, whose three Howard sons married her three Dacre daughters. His grandson James Leyburn was executed in 1583 for being "a Catholic traitor" and his geat-great-gansson was George Leyburn.