User:Financ/Low-threshold spikes

Project Proposal This is the proposal for our group project that will entail updating, expanding, and reformatting the current Wikipedia page for Low-threshold spikes. This is a group project and as such each group member will be responsible for researching and writing the new article. We will meet throughout the semester to accomplish this.

The following is a representation of what our proposed page will look like.

History
Evidence for low-threshold calcium current was first described in neurons of the inferior olivary nucleus (1981). This nucleus generates synchronous rhythmic activity which under certain conditions is manifested as a tremor.

Low-threshold spikes generate burst firing
Low-threshold calcium spikes (LTS) have been described in neurons from a variety of brain nuclei, including: inferior olive, thalamic relay, medial pontine reticular formation, lateral habenula, septum, deep cerebellar nuclei, CA1-CA3 of the hippocampus, association cortex, paraventricular and preoptic nuclei of the hypothalmus, dorsal raphe, globus pallidus, and subthalamic nucleus.

Research
Here we will discuss results from clamp and modeling studies of low-threshold calcium spikes (specifically from cells of a cat's lateral geniculate nucleus).

Parkinson's Disease
The low-threshold calcium spike hypothesis as it relates to the current model of Parkinson's disease

Relation to Parkinson's disease tremor

Division of Workload
We will meet weekly to discuss and research these areas that we have outlined. We will assign equal work to each member of the group to do further outside research on a particular topic and to add those findings to the page.